International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 531

Full Length Research Paper

Evaluation of leucocyte and its subgroups in iron deficiency anemia

Ali Özcan
  • Ali Özcan
  • Biochemistry Laboratory of Private Central Hospital, Istanbul, Turkey.
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Muzaffer Çakmak
  • Muzaffer Çakmak
  • Outpatient Clinics of Internal Medicine of Private Sema Hospital, Istanbul, Turkey.
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Ahmet Ruhi Toraman
  • Ahmet Ruhi Toraman
  • Health Services of Private Sema Hospital, Istanbul, Turkey.
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Aslıhan Çolak
  • Aslıhan Çolak
  • Outpatient Clinics of Internal Medicine of Private Sema Hospital, Istanbul, Turkey.
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Hamza Yazgan
  • Hamza Yazgan
  • Pediatric Clinics of Private Sema Hospital, Istanbul, Turkey.
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Mehmet Demirdöven
  • Mehmet Demirdöven
  • Pediatric Clinics of Private Sema Hospital, Istanbul, Turkey.
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Osman YokuÅŸ
  • Osman YokuÅŸ
  • Outpatient Clinics of Internal Medicine of Private Sema Hospital, Istanbul, Turkey.
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Ahmet Gürel
  • Ahmet Gürel
  • Biochemistry Laboratory of Private Sema Hospital, Istanbul, Turkey.
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  •  Accepted: 10 May 2011
  •  Published: 30 May 2011

Abstract

 

In this study, leukocyte, granulocyte, lymphocyte and monocyte count was evaluated in patients with iron deficiency anaemia. Complete blood count data from 84 patients (with iron deficiency anaemia) admitted to our hospital’s paediatrics and general medicine outpatient clinics, and 109 age- and sex-matched healthy controls, were evaluated retrospectively. Complete blood count analyses were performed with Micros 60, and serum iron and ferritin levels analyses were performed by auto analyzers. Whilst granulocyte count was higher in the group with iron deficiency anaemia, lymphocyte count was lower. No difference in monocyte count was found between the groups. Although total leukocyte count was higher in the group with anaemia, the difference was statistically insignificant. In anaemia, iron deficiency increases granulocyte but reduces lymphocyte count. The molecular basis of this dual effect of iron on cellular defence system is still, to a great extent, unexplained.

 

Key words: Iron deficiency anaemia, leucocyte, granulocyte, lymphocyte, monocyte.