International Journal of
Physical Sciences

  • Abbreviation: Int. J. Phys. Sci.
  • Language: English
  • ISSN: 1992-1950
  • DOI: 10.5897/IJPS
  • Start Year: 2006
  • Published Articles: 2578

Full Length Research Paper

Developing a spectrophotometric method for the estimation of albendazole in solid and suspension forms

Adedibu C. Tella*1, Ojeyemi M. Olabemiwo2, Musa O. Salawu 3 and Gabriel K. Obiyenwa1
1Department of Chemistry, P. M. B. 1515, University of llorin, Ilorin, Kwara State, Nigeria. 2Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria. 3Department of Biochemistry, P. M. B.1515, University of Ilorin, Ilorin, Kwara State, Nigeria.
Email: [email protected]

  •  Accepted: 16 February 2010
  •  Published: 30 April 2010

Abstract

A spectrophotometric method has been developed for the determination of albendazole in bulk, tablet and suspension dosage forms. Solution of albendazole in methanolic glacial acetic acid solution shows maximum absorbance at 235 nm. Beer’s law was obeyed in the concentration range of 2.5 - 20 μg/ml with molar absorptivity of 1.0815 × 104 mol-1 cm-1. The method was applied for the analysis of the drug in the pure, tablet and suspension forms. The slope and intercept of the equation of the regression line are 0.0310 and 0.00067 respectively. Correlation coefficient was found to be 0.9998. Results of percentage recovery showed that the method was not affected by the presence of common excipients. The proposed method is simple, sensitive, rapid, economical and could find application as an in -process quality control method for albendazole.

 

Key words: Albendazole, spectrophotometry, Beer’s law.

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