Abstract

 

The developments of gene expression profiling technology have deeply influenced the understanding of lung cancer biology. By microarray data, we constructed a regulation network to identify potential genes that are highly correlated to non-small cell lung cancer. Of the network, some transcription factors and target genes, including perturbation factors (PPARG), ETV4, TGFBR2 and ATP2A2, have been proved to be related to non-small cell lung cancer in previous study. We also found some new transcription factors and target genes may be related to non-small cell lung cancer, including SPI-1/PU.1, ETS2, and EGR1 and so on; these genes may be potential markers for non-small cell lung cancer.

 

Key words: Non-small cell lung cancer, transcription factors, regulation network.

 

Abbreviation

SCLC, Small-cell lung cancer: TRED, transcriptional regulatory element database; DEGs, differentially expressed genes; GO, gene ontology; IF, impact factor; PFs, perturbation factors; PPARG, PPARgamma; NSCLC, non-small cell lung cancer; VEGF-A, vascular endothelial growth factor-A; VWF, von Willebrand factor; ABC, ATP-binding cassette.