Abstract

The present investigation was directed to study the possible anti-genotoxic activity of orally administered crude garlic extract (GE) against cisplatin-induced genotoxicity in mouse by using chromosomal aberrations (CA’s) in germ cells and sperm morphology essay (SMA). Three different doses of garlic extract (125, 250, 500 mg/kg) were tested for their modulatory capacity on the mutagenecity exerted by CP (10 mg/kg, i.p.). GE alone did not induce any significant variation in the incidence of CA’s and frequency of aberrant sperms. Pretreatment of mice with GE for 7 days and simultaneously with a single dose of Cisplatin significantly reduced the frequency of CA’s and frequency of aberrant sperms, suggesting that the garlic extract modulates the CP induced genotoxicity in a dose dependent manner.

Key words: Garlic, chromosomal aberrations, germ cells.