March 2024

Computational prediction of small molecules targeting Lassa fever drug target using quantitative structure activity relationship (QSAR) and random forest algorithm

Lassa fever, an endemic viral hemorrhagic fever in West Africa, is attributed to the Lassa virus as its causative agent, and this disease has led to the untimely death of many people in the affected areas. At present, the available treatment options for Lassa fever are limited and there is need for new drugs. This study aims to use computational tools to predict the efficacy of small molecules that can target the Lassa...

Author(s): Angela Makolo and Pelumi Stephen Gboyega