Journal of
Clinical Medicine and Research

  • Abbreviation: J. Clin. Med. Res.
  • Language: English
  • ISSN: 2141-2235
  • DOI: 10.5897/JCMR
  • Start Year: 2009
  • Published Articles: 106

Full Length Research Paper

Sexual stimulatory effects of aqueous stem bark extract of Lophira laceolata in male Sprague Dawley rats

E. U. Etuk
  • E. U. Etuk
  • Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Search for this author on:
  • Google Scholar
A. A. Muhammad
  • A. A. Muhammad
  • Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Search for this author on:
  • Google Scholar
V. Igbokwe
  • V. Igbokwe
  • Department of Physiology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Search for this author on:
  • Google Scholar
R. U. Okolo
  • R. U. Okolo
  • Department of Anatomy, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
  • Search for this author on:
  • Google Scholar


  •  Accepted: 24 September 2009
  •  Published: 30 November 2009

Abstract

Lophira laceolata stem bark extract is commonly used by Herbal practitioners in Sokoto State, Nigeria to treat erectile dysfunction. The effect of oral administration of aqueous stem bark extract of the plant on sexual activity was investigated in male Sprague Dawley rats. Three doses (100, 200 and 300 mg/kg b. wt.) of the extract were administered to three groups of male Sprague Dawley rats and the sexual stimulatory effect as adjudged by mounting frequency (MF), mating, number of penile erection and ejaculation in the animals were recorded. The extract produced a significant (P < 0.05) and dose dependent increase in the listed parameters. The effect was compared to that of sildenafil a standard sexual performance enhancing agent and was shown to possess advantage of producing sexual enhancement in a sustained manner over sildenafil. This plant extract has the potentials of being developed into a sex performance enhancing drug. This finding supports the traditional use of this plant for the treatment of erectile dysfunction.

 

Key words: Lophira laceolata, erectile dysfunction, sexual enhancement.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 1 No. 2
Back to articles
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES