Abstract

Totally, 128 psychrophilic actinomycetes were isolated and 14 were found to be facultative psychrophilic which were selected to determine the antimycobacterial activity againstMycobacterium tuberculosis. The results showed that, four strains were active against the test organism M. tuberculosis. The active isolates screened in the present study were found to be highly effective and comes under Streptomycetes species (RH7 and RH8), Micromonosporaspecies (RH9) and Micropolyspora species (RH12). All the isolates capable of producing metabolites and their presence were confirmed by TLC. The ‘active culture filtrate’ showed ‘only one band’ and its functional Group Is low molecular weight neutral compounds and amines were determined based on their solubility and pH.

Key words: Psychrophilic actinomycetes, glaciers, drug resistance, Mycobacteriumtuberculosis, primary amines.