Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Antimutagenic extract from Tinospora cordifolia and its chemical composition

Upendra Sharma1, Manju Bala1, Praveen Kumar1, Geetanjali Rampal2, Neeraj Kumar1, Bikram Singh1* and Saroj Arora2
1Natural Plant Products Division, Institute of Himalayan Bioresource Technology (Council of Scientific and Industrial Research), Palampur, Himachal Pradesh 176 061, India. 2Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab 143 005, India.
Email: [email protected]

  •  Accepted: 23 July 2010
  •  Published: 04 December 2010

Abstract

Chemical constituents of Tinospora cordifolia n-hexane extract were characterized by Gas Chromatography-Mass Spectrometry (GC-MS) and column chromatography. 14 constituents were characterised by GC-MS analysis and column chromatography led to the isolation of β-sitosterol. The immunomodulatory activity of the extract was investigated by polymorphonuclear leucocytes function test and antimutagenic activity by using Salmonellahistidine tester strain TA 98. The extract exhibited potent antimutagenic activity and the IC50value was found to be 1033.98 µg/ 0.1 ml in co-incubation mode and 298.57 µg/ 0.1 ml in pre-incubation mode.

 

Key words: Tinospora cordifolia, n-hexane extract, gas chromatography-mass spectrometry, β-sitosterol, antimutagenicity, immunomodulatory activity.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 4 No. 23
Back to articles
  • Articles on Google by:
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES