Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Antispermatogenic effects of aqueous ethanolic extract of Hymenocardia acida stem bark in Wistar rats

Abu A. H.1* and Uchendu C. N.2
1Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Agriculture, P. M. B. 2373, Makurdi, Nigeria. 2Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
Email: [email protected]

  •  Accepted: 15 November 2010
  •  Published: 04 December 2010

Abstract

Oral administration of aqueous ethanolic extract of Hymenocardia acida stem bark for eight weeks caused a significant reduction (P < 0.05) in the weights of testes, epididymides, ventral prostrate, seminal vesicles and vasa differentia compared to the control. The treatment related decreases in sperm motility, count, viability and serum testosterone returned to near normal levels on withdrawal of the extract. The groups that received doses of 100, 200 and 400 mg/kg body weight of the extract showed 40, 0 and 0% fertility, respectively. H. acida stem bark extract adversely affected spermatogenesis in Wistar rats.

 

Key words: Albino rat, antispermatogenic, Hymenocardia acida, male reproduction.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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