Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

New amides from the seeds of Clausana lansium

W. Maneerat1, S. Tha-in1, S. Cheenpracha2, U. Prawat3 and S. Laphookhieo1*
1Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand. 2School of Science, University of Phayao, Maeka, Muang, Phayao 56000, Thailand. 3Department of Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Muang, Phuket 83000, Thailand.
Email: [email protected], [email protected]

  •  Accepted: 29 April 2011
  •  Published: 04 July 2011

Abstract

An investigation of Clausena lansium seed extract led to the isolation and identification of two new amides, clausenalansamide A (3) and clausenalansamide B (4), along with three known amides (1, 2 and 5). All structures were characterized by spectroscopic methods. Some of isolated compounds (1, 2 and 4) were evaluated for their anti-cancer activity against three human cancer cell lines, KB, MCF7 and NCI-H187. Compounds 1, 2 and 4 showed cytotoxicity against KB and NCI-H187 cancer cell lines with IC50 value ranging from 13.73 to 28.48 mg/ml. Compound 1 was also exhibited weakly cytotoxicity against MCF7 cell line with the IC50 value of 48.67 µg/ml while compounds 2 and 4 were found to be inactive.

 

Key words: Clausena lansium, Rutaceae, amides, cytotoxic activity, clausenalansamide A and B.

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