Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Anti-inflammatory properties of ethanolic root extract of Eremurus persicus (Jaub and Spach) Boiss, a Kurdish herbal remedy

Raffaella Gaggeri1,2#, Daniela Rossi1#, Ornella Azzolina1,, Karzan Mahmood Ahmed2,3, Antonia Avanzini4, Melissa Mantelli4, Davide Gozzini2,5, Mayra Paolillo6 and Simona Collina1,2*   #These authors equally contributed to this work.
1Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Viale Taramelli 12, Pavia 27100, Italy. 2Center for Studies and Researches in Ethno pharmacy (C.I.St.R.E.), University of Pavia, via Taramelli 12, 27100, Pavia, Italy. 3College of Science, Chemistry Department, Karkuk road, University of Salahaddin/Hawler, Kurdistan Region, Iraq. 4Pediatric Hematology/Oncology Department, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 19, 27100 Pavia, Italy. 5Department of Chemistry, University of Pavia, Viale Taramelli 12, Pavia 27100, Italy. 6Department of Drug Sciences, Pharmacology Section, University of Pavia, Viale Taramelli 12, Pavia 27100, Italy.
Email: [email protected]

  •  Accepted: 15 May 2013
  •  Published: 17 June 2013

Abstract

This study reports for the first time a preliminary phytochemical and biological screening of ethanolic extract (EE) from roots of Eremurus persicus (Jaub and Spach) Boiss, a Kurdish herbal remedy for treating inflammatory disorders. The phytochemical analysis was performed by thin layer chromatography and it revealed the presence of flavonoids and antracenones. The total phenolic compounds were also determined. Free radical scavenging (FRS) effect was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay and the anti-inflammatory activity investigated by evaluating the inhibition of in vitro lymphocyte proliferation. To exclude citotoxic effect of EE, cell viability tests were also performed. Overall, biological investigation showed that the E. persicus (Jaub and Spach) Boiss root EE possess an interesting anti-inflammatory activity without cytotoxic effects.

 

Key words: Anti-inflammatory activity, Kurdish ethnomedicine, Eremurus persicus (Jaub and Spach) Boiss, ethanolic root extract.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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