Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

In vitro anthelmintic activity of stem and root barks of Alstonia boonei De Wild

Michael Worlako Klu
  • Michael Worlako Klu
  • Department of Pharmaceutical Science, Central University College, Accra, Ghana.
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John Antwi Apenteng
  • John Antwi Apenteng
  • Department of Pharmaceutical Science, Central University College, Accra, Ghana.
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David Ntinagyei Mintah
  • David Ntinagyei Mintah
  • Department of Pharmaceutical Science, Central University College, Accra, Ghana.
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Bright Selorm Addy
  • Bright Selorm Addy
  • Department of Pharmaceutical Science, Central University College, Accra, Ghana.
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Ivan Nyarko-Danquah
  • Ivan Nyarko-Danquah
  • Department of Pharmaceutical Science, Central University College, Accra, Ghana.
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Samuel Boakye Afriyie
  • Samuel Boakye Afriyie
  • Department of Pharmaceutical Science, Central University College, Accra, Ghana.
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  •  Received: 16 December 2015
  •  Accepted: 23 February 2016
  •  Published: 03 April 2016

Abstract

Alstonia boonei De Wild ethanol extracts of the stem bark (ABSB) and root bark (ABRB) were evaluated for possible anthelmintic activity. Three different concentrations of each extract (50, 100 and 150 mg/ml) were evaluated for in vitro anthelmintic activity by determining the effects of the extracts on the paralysis and death times of Pheretima posthuma. Mebendazole (MBZ) 15 mg/mg was used as reference anthelmintic. ABSB and ABRB demonstrated a concentration dependent anthelmintic activity with a reduction in paralytic and death times upon increase in the concentration of the extracts. ABSB revealed better anthelmintic activity than ABRB at all concentrations tested. ABSB also revealed a significant paralytic time (p<0.01) at 150 mg/ml with reference to MBZ. Phytochemical screening revealed the presence of alkaloids, tannins, flavonoids saponins and glycosides in ABSB and ABRB.

Key words: Alstonia boonei, anthelmintic, Pheretima posthuma, death time, paralytic time.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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