Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Comparative in vivo evaluation of the trypanocidal activities of aqueous leaf, stem-bark and root extracts of Khaya senegalensis on Trypanosoma evansi

A. A. Adeiza1*, A. Mohammed2 and M. Mamman3
1Animal Health and Husbandry Department, College of Agriculture and Animal Science, Ahmadu Bello University, P. M. B. 2134, Mando Road, Kaduna, Nigeria. 2Animal Production Technology Department, College of Agriculture and Animal Science, Ahmadu Bello University, P. M. B. 2134, Mando Road, Kaduna, Nigeria. 3National Institute for Trypanosomiasis Research, Surame Road, Kaduna, Nigeria.
Email: [email protected]

  •  Accepted: 20 July 2010
  •  Published: 04 September 2010

Abstract

The effects of three different parts of Khaya senegalensis, commonly used in the traditional treatment of diseases in Northern Nigeria was examined in Trypanosoma evansi infected rats. At a dose of 120 mg/ml body weight for 3 consecutive days, the aqueous stem bark extract completely suppressed parasite establishment. The dose cured the experimentally infected rats in 9 days. The aqueous leaf extract showed a weak trypanocidal activity while the stem bark extract showed the most activity that is dose dependent. The results suggested that traditional use of K. senegalensis extracts has a pharmacological basis.

 

Key words: Khaya senegalensis, Trypanosoma evansi, trypanocidal activity, in vivo, parasitaemia

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This article is published under the terms of the Creative Commons Attribution License 4.0

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