Abstract

In the present study, the anti-hyperglycemic and antioxidant potential of the Securigerasecuridaca (L.) seed suspension in alloxan-induced hyperglycemic rats was investigated. The male Wistar rats (180 to 220 g) were divided in three groups and treated orally for 4 days as follow: group I, the control, was fed 10 ml/kg/day of distilled water, groups II and III were gavaged 2 and 4 g/kg/day of S. securidaca (L.) seed suspension, respectively. One hour after final feeding, alloxan was injected subcutaneously (70 mg/kg B.W). At the end of the experimental period (after 24, 48 or 72 h of alloxan injection), antioxidant activity, fasting glucose and insulin levels were determined. The administration of suspension (2 g/kg/d or 4 g/kg/day) significantly reduced elevated serum glucose concentration induced by alloxan and that was prominent following 24, 48 and 72 h of alloxan injection. Serum antioxidant activity in the low (2 g/kg/d) and high (4 g/kg/d) doses of suspension treated rats was significantly higher at 24, 48 and 72 h after alloxan injection as compared to control rats. These results indicate protective effect of S. securidaca (L.) suspension against alloxan-induced hyperglycemia and oxidative stress in rats.

Key words: Hyperglycemia, alloxan, Securigera securidaca, glucose, antioxidant activity.