Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Evaluation of hypolipidemic and potential antioxidant effects of Pigeon pea (Cajanus cajan (l) mill sp.) leaves in alloxan-induced hyperglycemic rats

Akinloye O. A.* and Solanke, O. O.
Department of Biochemistry, College of Natural Sciences, University of Agriculture, P. M. B. 2240 Abeokuta, Ogun-State, Nigeria.
Email: [email protected]

  •  Accepted: 15 March 2011
  •  Published: 18 June 2011

Abstract

Antioxidant and hypolipidemic activity of the methanolic leaf extract from Cajanus cajan was carried out in alloxan induced hyperglycemic rats. A significant (p<0.05) reduction in the levels of blood glucose, serum triglyceride, cholesterol, high density lipoprotein and low density lipoprotein cholesterol was observed in the hyperglycemic-extract treated rats. The administration of the extract (200 mg/kg) also caused a reduction in urea, creatinine and malondialdehyde levels in hyperglycemic rats. The extract was found to be able bring about 34.4 and 32.16% decrease in the activities of ALT and AST respectively in the hyperglycemic-treated rats compared to untreated group. Antioxidant activity of the extract was also confirmed through in vitro studies.

 

Key words: Cajanus cajan, hypolipidemic effect, antioxidant activity.

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