Abstract

This study evaluated flavonoids extracted from lotus (Nelumbo nuficera Gaertn) on reducing hyperglycemia and hyperlipidemia in alloxan-induced diabetic mice. flavonoids from lotus(FLL) was orally administered once a day after 3 days of alloxan -induction at 50 and 200 mg/kg for 28 day, and the results showed that fasting blood glucose ,serum TC and TG levels were significantly decreased, whereas serum HDL-c level were increased. The dosage of 200 mg/kg is more effective than that of 50 mg/kg. In addition, FLL did not exhibit any toxic symptoms in the limited toxicity evaluation in male mice. The above results suggested thatFLL could control blood glucose and modulate the metabolism of glucose and blood lipid. So we conclude that the FLL should be evaluated as a candidate for future studies on diabetes mellitus.

Key words: Hypoglycemic, hypolipidemic, flavonoids from lotus leaf.