Full Length Research Paper
Abstract
A systematic molecular fragmentation pathway (SMFP) was designed as an identifier to detect isoflavan-cinnamylphenols in methanol extract of Dalbergia congestiflora. Comprehensive mass spectral fragmentation patterns for extract of D. congestiflora were established using high-performance liquid chromatography (HPLC)/mass spectrometry (MS) equipment. Seven (1 to 7) tautomeric forms of isoflavan-cinnamylphenols (IFCPs) were identified by electron ionization mass spectroscopy (ESI-MS). These compounds were cytotoxic to the HeLa cervical cancer cell line. Compounds 1, 2 and 3 showed significant activity against HeLa cancer cell line in vitro with IC50 values in the range 1.70 to 3.34 µg/ml. Compounds 4 to 7 showed moderate cytotoxicity with IC50 values ranging from 2.23 to 8.67 µg/ml.
Key words: Dalbergia congestiflora, isoflavan-cinnamylphenols, tautomeric form, mass spectrometry.
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