Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Short Communication

Effect of leaves of Apocynum venetum L. on the activity of MAO in mice

Benhong Zhou1*, Xiaojun Li2, Zhenpeng Qiu2 and Gang Liu1
1Department of Pharmacy, Renmin Hospital, Wuhan University, Wuhan 430060, PR China. 2College of Pharmacy, Wuhan University, Wuhan 430072, PR China.
Email: [email protected]

  •  Accepted: 01 April 2011
  •  Published: 18 June 2011

Abstract

The purpose of this study was to evaluate the effect of leaves of Apocynum venetum L.(AV) on the monoamine oxidase (MAO) activity in mice whole brain. After 7 days oral administration, we assayed spectrophotometrically the activity of MAO. The ethanolic extract of leaves of A. venetum (EAV) showed a tendency to inhibit MAO activity in animal brain. However, the aqueous phase of EAV (EAV-4) significantly inhibits the MAO activity. The effect of fluoxetine on activity of MAO was not marked. The aqueous phase of ethanolic extracts of AV significantly inhibited the activity of MAO, which might be the active part of antidepressant effect of AV.

 

Key words: Apocynum venetum L., monoamine oxidase, monoamines.

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