Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Synthesis, structural determination and protective effects on cultured anoxia/reoxygen injury myocardiocytes of ocotillol-type derivatives

Yi Bi1, Jingwei Tian2, Liang Wang1, Fenglan Zhao1, Jiangfeng Zhang1, Nan Wang1, Haijun Sun1and Qingguo Meng1*
1Department of Medicinal Chemistry, School of Pharmacy, Yantai University, 32 Qingquan Road, Yantai 264005, China. 2Department of pharmacology, School of Pharmacy, Yantai University, 32 Qingquan Road, Yantai 264005, China.
Email: [email protected]

  •  Accepted: 31 March 2011
  •  Published: 04 June 2011

Abstract

The octillol-type derivatives 3 and its epimer 4 had been designed and synthesized from 20(S)-panaxadiol. The structures of 3 and 4 were confirmed by ESI-MS, 1H-NMR, 13C-NMR and X-ray diffraction. The crystal data showed the configuration of C-24 of two epimers as R-form (3) and S-form (4, epimer) respectively. Compound 3 was evaluated in vitro for its protective effect on cultured myocardiocytes with anoxia/reoxygen injury and compound 4 had none of this activity.

 

Key words: Octillol-type derivative, epimer, X-ray diffraction, protective effect, cultured myocardiocytes with anoxia/reoxygen injury.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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