Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3832

Full Length Research Paper

In vitro antiviral activity of diterpenes isolated from the Brazilian brown alga Canistrocarpus cervicornis

Magui Aparecida Vallim1, Juliana Eymara Barbosa1, Diana Negrão Cavalcanti1, Joel Campos De-Paula2, Viveca Antonia Giongo Galvão da Silva1, Valéria Laneuville Teixeira1* and Izabel Christina Nunes de Palmer Paixão1,3
1Programa de Pós-Graduação em Biologia Marinha, Instituto de Biologia, Universidade Federal Fluminense, P. O.Box 100.644, CEP 24001-970, Niterói, RJ, Brazil. 2Instituto de Biociências, Universidade Federal do Estado do Rio de Janeiro, Avenida Pasteur 458, CEP 22290-240, Urca, Rio de Janeiro, RJ, Brazil. 3Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Email: [email protected]

  •  Accepted: 29 September 2010
  •  Published: 18 November 2010

Abstract

They describe in this paper that the dolastane diterpenes 4-hydroxy-9,14-dihydroxydolasta-1(15),7-diene (1) and 4,7,14-trihydroxydolasta-1(15),8-diene (2), isolated from the marine brown alga Canistrocarpus cervicornis inhibited HSV-1 infection in Vero cells. The concentration required to inhibit HSV-1 replication was not cytotoxic. Their results suggest that the structures of diterpenes 1 and 2, dolastane diterpenes from Brazilian brown algae, are promising for future antiviral drugs.

 

Key words: Canistrocarpus cervicornis, dictyotaceae, phaeophyceae, dolastane diterpene, cytotoxicity, antiviral against HSV-1.

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