Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Evaluation of antioxidant potential of Ficus religiosa (Linn.) roots against carbon tetrachloride-induced liver injury

Vivek Kumar Gupta1*, Monika Gupta1 and Surendra Kumar Sharma2
1ASBASJSM College of Pharmacy, Bela (Ropar), Punjab, India. 2Department of Pharm. Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana), India.
Email: [email protected]

  •  Accepted: 20 January 2011
  •  Published: 04 May 2011

Abstract

Antioxidant activity of the aqueous (FRWE) and alcoholic extract (FRAE) of Ficus religiosaroots was evaluated in rats by inducing liver injury with carbon tetrachloride:olive oil (1:1). The extract possessed remarkable antioxidant activity showing increased levels of glutathione peroxidase (GPX), glutathione S-transferase (GST), glutathione reductase (GRD), superoxide dismutase (SOD) and catalase (CAT) and decreased level of lipid peroxidation (LPO). F. religiosa root extracts, FRWE and FRAE, at a dose level of 500 mg/kg showed significant antioxidant activity against carbon tetrachloride-induced liver injury in rats.

 

Key words: Superoxide dismutase, catalase, marker enzymes in liver, antioxidant activity.

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