Abstract

The n-butanol phase of the methanolic leaves extract of Microtrichia perotitii DC was studied for its analgesic and anti-inflammatory activities. Both percent inhibition obtained from analgesic (59.30% for 100 mg/kg, 33.90% for 50 mg/kg and 69.20% for 25 mg/kg i.p) and anti-inflammatory (values for 25, 50 and 100 mg/kg were found significantly different at P < 05, P < 0.01 and P < 0.001) (mean paw diameter in hours) studies has shown that the leaves have very strong activity to prevent pains (writhing) in the central system and motor performance of the mice as  well as the growth of oedema in the hind paw of the rats respectively. The analgesic effect is dosage independent while the anti-inflammatory effect is dosage dependent and all these activities could be associated with the type of phytochemicals likely to be present in the leaves of plant.

Key words: Microtrichia perotitii, n-butanol phase, analgesic, anti-inflammatory