Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3839

Full Length Research Paper

Wound healing effects of Commiphora swynnertonii resin formulations using rat as model animal

James Richard Mushi
  • James Richard Mushi
  • Department of Veterinary Physiology, Biochemistry and Pharmacology, Sokoine University of Agriculture, Morogoro, Tanzania.
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Benigni Alfred Temba
  • Benigni Alfred Temba
  • Department of Veterinary Physiology, Biochemistry and Pharmacology, Sokoine University of Agriculture, Morogoro, Tanzania.
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Shaban Mshamu
  • Shaban Mshamu
  • Department of Veterinary Physiology, Biochemistry and Pharmacology, Sokoine University of Agriculture, Morogoro, Tanzania.
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Robert Arsen Max
  • Robert Arsen Max
  • Department of Veterinary Physiology, Biochemistry and Pharmacology, Sokoine University of Agriculture, Morogoro, Tanzania.
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Gaymary George Bakari
  • Gaymary George Bakari
  • Department of Veterinary Physiology, Biochemistry and Pharmacology, Sokoine University of Agriculture, Morogoro, Tanzania.
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  •  Received: 22 April 2024
  •  Accepted: 13 June 2024
  •  Published: 31 July 2024

Abstract

Commiphora swynnertonii (Burceraceae) is commonly used for the treatment of various ailments, including arthritis, wounds, and skin conditions. In this study, the effects of various formulations of the tree resin on wound healing were evaluated in rats through skin contracture and histological changes. Body weights were also monitored during the experiments. Tree resins were prepared at 0, 2.5, 5, 10, 15, and 30% v/v concentrations to create various formulations of two products, namely wound gel and wound spray. The formulations were applied on wounds cut on rats' skins at cervical regions and monitored for 34 days. Wound contraction diameters were measured in millimeters, and fibrous tissue formation was assessed under the microscope. Both formulations sped up wound healing by contractions and fibroblast migration in dose-dependent manners, with (R2 = 95.6; P <0.01) for spray and (R2 = 69.7; P<0.05) for the gels. This study indicates that wound spray and gel formulations from the plant resin accelerate wound healing without affecting weight.

Key words: Commiphora swynnertonii, resin, wound healing activity, rats.