Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Sub-chronic toxicity of the leaf aqueous extract of Bidenspilosa Linn (Asteraceae) in male and female rats

Orélien Sylvain Mtopi Bopda
  • Orélien Sylvain Mtopi Bopda
  • Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, P.O. Box 63 Buea, Cameroon.
  • Google Scholar
Frida Longo
  • Frida Longo
  • Department of Biological Sciences, ENS, University of Yaounde I, P.O. Box 47, Yaounde, Cameroon.
  • Google Scholar
Fidéliste Boade
  • Fidéliste Boade
  • Department of Biological Sciences, ENS, University of Yaounde I, P.O. Box 47, Yaounde, Cameroon.
  • Google Scholar
Paul Desire Djomeni Dzeufiet
  • Paul Desire Djomeni Dzeufiet
  • Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 712, Yaounde, Cameroon.
  • Google Scholar
Theophile Dimo
  • Theophile Dimo
  • Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 712, Yaounde, Cameroon.
  • Google Scholar


  •  Received: 29 August 2016
  •  Published: 10 October 2016

References

Adewole SO,Ojewole JA (2008). Protective effects of Annonamuricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats. Afr. J. Tradit. Complement. Altern. Med. 6(1):30-41.

 

Andrade-Neto V, Brandao MGL, Oliveira FQ,Casali VWD, Njaine B, Zalis MG, Oliveira, Krettli AU (2004). Antimalarial activity of Bidenspilosa L. (Asteraceae) ethanol extracts from wild plants collected in various localities or plants cultivated in humus soil. Phytother. Res. 18(8):634-639.
Crossref

 
 

Cárdenas MB, Álvarez CS, Morgado EB, Gutiérrez MG, Monteagudo GL, Suarez OS (2006). Toxicological evaluation of an infusion of Bidens pilosa. Pharmacologyonline 3:428-434.

 
 

Brandao MGL, Krettli AU, Soares LSR, Nery CGC, Marinuzzi HC (1997). Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compound. J. Ethnopharmacol. 57(2):131-8.
Crossref

 
 

Cerisier A, Tostain J, Rossi D (2004). Androgens and the cardiovascular system. Prog. Urol. 14(5):731-743.

 
 

Chiang YM, Chuang DY, Wang SY, Kuo YH, Tsai PW, Shyur LF (2004). Metaboliteprofiling and chemopreventive bioactivity of plants extracts from Bidens pilosa. J. Ethnopharmacol. 95(2-3):409-19.
Crossref

 
 

Chin H, Lin C, Tang K (1996). The hepatoprotective effects of Taiwan folk medicine ham-hong-chho in rats. Am. J. Chinese Med. 24(3-4):231-240.

 
 

Dimo T, Rakotonirina S, Tan P, Azay J, Dongo ECros G (2002). Leaf methanol extract of Bidens pilosa prevents and attenuates the hypertension induced by high-fructose diet in Wistar rats. J. Ethnopharmacol. 83(3):183-91.
Crossref

 
 

Dimo T, Nguelefack T B, Kamtchouing P, Dongo E, Rakotonirina A, Rakotonirina S V (1999). Effets hypotensifs de l'extrait au méthanol de Bidens pilosa Linn. chez le rat hypertendu. Acad. Sci. 32:323-329.
Crossref

 
 

Duke JA (1997). The Green Pharmacy: New Discoveries in Herbal Remedies for Common Diseases and Conditions from the World's Foremost Authorities on Healing Herbs. Rodale. Available at: www.greenpharmacy.com

 
 

Ezeonwumelu JOC, Julius AK, Muhoho CN, Ajayi AM, Oyewale AA, Tanayen JK, Balogun SO, Ibrahim A, Adzu B, Adiukwu CP, Oloro J, Kiplagat DM, Goji ADT, Okoruwa AG, Onchweri AN, Reddy PMK (2011). Biochemical and Histological Studies of Aqueous Extract of Bidens pilosa Leaves from Ugandan Rift Valley in Rats. Br. J. Pharmacol. Toxicol. 2(6):302-309.

 
 

Ganter P, Jolles G (1970). In tissus conjonctifs in histochimie normales et pathologique, Gauthier-Villars Paris. pp. 1045-1126.

 
 

Geissberger P, Sequin U (1991). Constituents of Bidenspilosa L. Do the components found so far explain the use of this plant in traditional medicine?Act. Trop. 48(4): 251-261.
Crossref

 
 

Hartwell LH, Schwartz JM (2009). Evaluation and Management of Abnormal Liver Chemistry Tests in the Asymptomatic Outpatient. J. Clin. Outcomes Manage. 16(11):525-534.

 
 

Hou D, Guo Q, LiY, Li L, Wang Q,Yi Q, Tang M (1989). Effects of anticancer No.8 drugs on the experimental tumours in mice. J. China Pharm. Univ. 20(6):348-350.

 
 

Lakmichi H, Bakhtaoui FZ, Gadhi CA, Ezoubeiri A, El Jahiri Y, El Mansouri A, Zrara I, Loutfi K (2010). Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiolatelephiifolia Pourr. (Caryophyllaceae) in Rodents. Evid. Based Complement. Altern. Med. 2013:317090.

 
 

Li-Ping Y, Fei-Hu C, Lu L, Peng-Fei D, Hu B, Ming-Mei Z, Li-Juan X (2008). Protective effects of total flavonoids of Bidens pilosa L. (TFB) on animal liver injury and liver fibrosis. J. Ethnopharmacol. 116(3):539-46.
Crossref

 
 

Longo F, Rakotonirina S, Rakotonirina A, Savineau JP (2008). In Vivo and In Vitro Effects of Bidens Pilosa L. (Asteraceae) Leaf Aqueous and Ethanol Extracts on Primed-Oestrogenized Rat Uterine Muscle. Afr. J. Tradit. Complement. Altern. Med. 5(1):79-91.

 
 

Mates M (2004). Haematology review. Pearson Education inc. Publishing as Benjamin Cummings. 83 p.

 
 

Mbaka GO, Adeyemi OO, Oremosu AA (2010). Acute and sub-chronic toxicity studies of the ethanol extract of the leaves of Sphenocentrum jollyanum (Menispermaceae). Agric. Biol. J. N. Am. 1(3):265-272.
Crossref

 
 

Morgan DL, Peck SD (1988). The Use of Red Cell Distribution Width in the Detection of Iron Deficiency in Chronic Haemodialysis Patients. Am. J. Clin. Pathol. 89:513-515.
Crossref

 
 

NIH (1996). NIH Guide for the Care and use of LaboratoryAnimals. NIH Publication, No. 23-83.

 
 

Pereira R, Ibrahim T, Lucchetti L, da Silva A, Gonçalves de Moraes V (1999). Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidenspilosa L. Immunopharmacology 43:31.
Crossref

 
 

Suzigan M, Battochio A, Coelho K, Coelho C (2009). An aqueous extract of Bidens pilosa L. protects liver from cholestatic disease experimental study in young rats. Acta Cirúrg. Bras. 24(5):347-352.

 
 

Sundararajan P, Dey A, Smith A, Gana Doss A, Rajappan M, Natarajan S (2006). Studies of anticancer and antipyretic activity of Bidens pilosa whole plant. Afr. Health Sci. 6(1):27-30.

 
 

OECD (2006). Repeated Dose 28-day oral Toxicity Study in Rodents; Updated with Parameters for endocrine effects. Draft Updated Test Guideline 407. 

View

 
 

Otimenyin SO, Kolawole JA, Nwosu M (2010). Pharmacological basis for the continual use of the root of sennasiamea in traditional medicine. Intern. J. Pharm. Biol. Sci. 1(3):1-9.

 
 

Witthawaskul P, Panthong A, Kanjanapothi D, Taesothikul T, Lertprasertsuke N (2003). Acute and subacute toxicities of the saponin mixture isolated from Schefflera leucantha Viguier. J. Pharmacol. 89(1):115-21.
Crossref

 
 

Zimmerman M (1993). Ethical guidelines for investigation of experimental pain in conscious animals. Pain 16:109-110.
Crossref