Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Review

Future molecular medicine from white frangipani (Plumeria alba L.): A review

Barry Anggoro
  • Barry Anggoro
  • Master of Science, Faculty of Pharmacy, Sanata Dharma University, Yogyakarta Indonesia.
  • Google Scholar
Enade Istyastono
  • Enade Istyastono
  • Master of Science, Faculty of Pharmacy, Sanata Dharma University, Yogyakarta Indonesia.
  • Google Scholar
Maywan Hariono
  • Maywan Hariono
  • Master of Science, Faculty of Pharmacy, Sanata Dharma University, Yogyakarta Indonesia.
  • Google Scholar


  •  Received: 19 March 2020
  •  Accepted: 07 September 2020
  •  Published: 31 October 2020

References

Alberts P, Engblom L, Edling N, Forsgren M, Klingström G, Larsson C, Rönquist-Nii Y, Öhman B, Abrahmsén L (2002). Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia 45(11):1528-1532.
Crossref

 

Anggoro AB (2020). Uji Penghambatan Enzim Matrix Metalloproteinase-9 (MMP-9) Fraksi Aktif Daun Kamboja Putih (Plumeria alba L.). Thesis. Sanata Dharma University, Yogyakarta.

 

Artis DR, Lin JJ, Zhang C, Wang W, Mehra U, Perreault M, Erbe D, Krupka HI, England BP, Arnold J, Plotnikov AN, Marimuthu A, Nguyen H, Will S, Signaevsky M, Kral J, Cantwell J, Settachatgull C, Yan DS, Fong D, Oh A, Shi S, Womack P, Powell B, Habets G, West BL, Zhang KYJ, Milburn MV, Vlasuk GP, Hirth KP, Nolop K, Bollag G, Ibrahim PN, Tobin JF (2009). Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent. Proceedings of the National Academy of Sciences of the United States of America 106(1):262-267.
Crossref

 

Bebernitz GR, Beaulieu V, Dale BA, Deacon R, Duttaroy A, Gao J, Grondine MS, Gupta RC, Kakmak M, Kavana M, Kirman LC, Liang J, Maniara WM, Munshi S, Nadkarni SS, Schuster HF, Stams T, St. Denny I, Taslimi PM, Vash B, Caplan S (2009). Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes. Journal of Medicinal Chemistry 52(19):6142-6152.
Crossref

 

Beutler E (1969). Effect of flavin compounds on glutathione reductase activity: in vivo and in vitro studies. Journal of Clinical Investigation 48(10):1957-1966.
Crossref

 

Boampong JN, Ameyaw EO, Kyei S, Aboagye B, Asare K, Afoakwah R, Boye A, Donfack JH (2013). In vivo antimalarial activity of stem bark extracts of Plumeria alba against Plasmodium berghei in imprinting control region mice. Reports in Parasitology 3:19.
Crossref

 

Bregman-Cohen A, Deri B, Maimon S, Pazy Y, Fishman A (2018). Altering 2-Hydroxybiphenyl 3-Monooxygenase Regioselectivity by Protein Engineering for the Production of a New Antioxidant. ChemBioChem 19(6):583-590.
Crossref

 

Buckley NA, Sanders P (2000). Cardiovascular Adverse Effects of Antipsychotic Drugs. Drug Safety 23(3):215-228.
Crossref

 

Camps M, Rückle T, Ji H, Ardissone V, Rintelen F, Shaw J, Ferrandi C, Chabert C, Gillieron C, Françon B, Martin T, Gretener D, Perrin D, Leroy D, Vitte P, Hirsch E, Wymann MP, Cirillo R, Schwarz MK, Rommel C (2005). Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nature Medicine 11(9):936-943.
Crossref

 

Chen JCH, Miercke LJW, Krucinski J, Starr JR, Saenz G, Wang X, Spilburg CA, Lange LG, Ellsworth JL, Stroud RM. (1998). Structure of Bovine Pancreatic Cholesterol Esterase at 1.6 Å: Novel Structural Features Involved in Lipase Activation. Biochemistry 37(15):5107-5117.
Crossref

 

Choi HJ, Kang SW, Yang CH, Rhee SG, Ryu SE (1998). Crystal structure of a novel human peroxidase enzyme at 2.0 Å resolution. Nature Structural Biology 5(5):400-406.
Crossref

 

Choudhary M, Kumar V, Gupta P, Singh S (2014). Investigation of Antiarthritic Potential of Plumeria alba L. Leaves in Acute and Chronic Models of Arthritis. BioMed Research International 2014:1-12.
Crossref

 

Cutts JH, Beer CT, Noble AL (1960). Biological Properties of Vincaleukoblastine , an Alkaloid in Vinca rosea Linn , with Reference to Its Antitumor Action. American Cancer Society 20(7):1023-1031.

 

Dawood HD, Hassan RA, Abdel-fattah SM (2016). Antioxidant Activity Evaluation of Methanolic Extract and Crude Polysaccharides from Plumeria alba L. Leaves. International Journal of Advance Research 4(5):1688-1701.
Crossref

 

Ebrahim N, Kershi RM, Rastrelli L (2013). Free radical scavenging activity and anthocyanin in flower of Adenium obesum collected from Yemen. Journal of Pharmacy and Phytotherapeutics 1(5):5-7.

 

El-kashef DF, Hamed AN., Khalil HE, Kamel MS (2015). Triterpenes and sterols of family Apocynaceae (2013-1955), A review. Journal of Pharmacognosy and Phytochemistry 4(2):21-39.

 

Erdemoglu N, Küpeli E, YeÅŸilada E (2003). Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. Journal of Ethnopharmacology 89(1):123-129.
Crossref

 

Gasser B, Saloheimo M, Rinas U, Dragosits M, Rodríguez-Carmona E, Baumann K, Giuliani M, Parrilli E, Branduardi P, Lang C, Porro D, Ferrer P, Tutino M, Mattanovich D, Villaverde A (2008). Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview. Microbial Cell Factories 7(1):1-18.
Crossref

 

Geetha T, Varalakshmi P (2001). Anti-inflammatory activity of lupeol and lupeol linoleate in rats. Journal of Ethnopharmacology 76(1):77-80.
Crossref

 

Ghosh S, Suryawanshi SA (2001). Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Indian Journal of Experimental Biology 39(8):748-759.

 

Golden E, Karton A, Vrielink A (2014). High-resolution structures of cholesterol oxidase in the reduced state provide insights into redox stabilization. Acta Crystallographica Section D Biological Crystallography 70(12):3155-3166.
Crossref

 

Graham JG, Quinn ML, Fabricant DS, Farnsworth NR (2000). Plants used against cancer - an extension of the work of Jonathan Hartwell. Journal of Ethnopharmacology 73(3):347-377.
Crossref

 

Guédez G, Hipp K, Windeisen V, Derrer B, Gengenbacher M, Böttcher B, Sinning I, Kappes B, Tews I (2012). Assembly of the Eukaryotic PLP-Synthase Complex from Plasmodium and Activation of the Pdx1 Enzyme. Structure 20(1):172-184.
Crossref

 

Gupta M, Rakhi, Yadaf N, Saroj, Pinky, Siksha, Manisha, Priyanka, Amit, Rahul, Sumit, Ankit (2016). Research Article Phytochemical screening of leaves of Plumeria alba and Plumeria acuminata. Journal of Chemical and Pharmaceutical Research 8(5):354-358.

 

György L, Ross D, Bodell WJ (1993). Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells, mouse bone marrow macrophages and human bone marrow. Carcinogenesis 14(11):2329-2334.
Crossref

 

Han S, Forman MD, Loulakis P, Rosner MH, Xie Z, Wang H, Danley DE, Yuan W, Schafer J, Xu Z (2006). Crystal Structure of Nicotinic Acid Mononucleotide Adenylyltransferase from Staphyloccocus aureus: Structural Basis for NaAD Interaction in Functional Dimer. Journal of Molecular Biology 360(4):814-825.
Crossref

 

Hanan N, Chiu H, Ramachandran M, Tung W, Mohamad Zain N, Yahaya N, Lim V (2018). Cytotoxicity of Plant-Mediated Synthesis of Metallic Nanoparticles: A Systematic Review. International Journal of Molecular Sciences 19(6):1725.
Crossref

 

Harwig J, Scott PM (1971). Brine Shrimp (Artemia salina L.) Larvae as a Screening System for Fungal Toxins. Applied Microbiology 21(6):1011-1016.
Crossref

 

Heath RJ, Rock CO (1995). Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli. Journal of Biological Chemistry 270(44):26538-26542.
Crossref

 

Heck AM, Yanovski JA, Calis KA (2000). Orlistat, a new lipase inhibitor for the management of obesity. Pharmacotherapy 20(3):270-279.
Crossref

 

Heynekamp JJ, Hunsaker LA, Vander Jagt TA, Royer RE, Deck LM, Vander Jagt DL (2008). Isocoumarin-based inhibitors of pancreatic cholesterol esterase. Bioorganic and Medicinal Chemistry 16(9):5285-5294.
Crossref

 

Hidajati N, Qodriyah (2018). from White Frangipani Leaves (Plumeria alba). In Proceedings of the Seminar Nasional Kimia - National Seminar on Chemistry (SNK 2018) Toxicity, Surabaya: Atlantis Press.

 

Hiranuma T, Iwao K, Kitamura K, Matsumiya T, Oka T (1997). Almost complete protection from [Met5]-enkephalin-Arg6-Gly7-Leu8 (Met- enk-RGL) hydrolysis in membrane preparations by the combination of amastatin, captopril and phosphoramidon. Journal of Pharmacology and Experimental Therapeutics 281(2):769-774.

 

Holmes EC (1998). Molecular epidemiology and evolution of emerging infectious diseases. British Medical Bulletin 54(3):533-543.
Crossref

 

Hosie L, Sutton LD, Quinn DM (1987). p-Nitrophenyl and cholesteryl-N-alkyl carbamates as inhibitors of cholesterol esterase. Journal of Biological Chemistry 262(1):260-264.

 

Jamal JA, Ghafar ZA, Husain K (2011). Medicinal Plants used for Postnatal Care in Malay Traditional Medicine in the Peninsular Malaysia. Pharmacognosy Journal 3(24):15-24.
Crossref

 

Jiwantono F, Purwanta M, Setiawati Y (2017). Uji Efektifitas Ekstrak Bunga Kamboja (Plumeria alba) Sebagai Antibakteri Terhadap Streptococcus pyogenes. Jurnal Kedokteran Syiah Kuala 17(3):147-155.
Crossref

 

Jung S, Jeong DG, Lee MS, Lee J, Kim HK, Ryu SE, Park BC, Kim JH, Kim SJ (2008). Structural basis for the cold adaptation of psychrophilic M37 lipase from Photobacterium lipolyticum. Proteins: Structure, Function, and Bioinformatics 71(1):476-484.
Crossref

 

Kadébé ZT, Metowogo K, Bakoma B, Poevi Lawson-Evi S, Eklu-Gadegbeku K, Aklikokou K, Gbeassor M (2016). Antidiabetic Activity of Plumeria Alba Linn (Apocynaceae) Root Extract and Fractions in Streptozotocin-Induced Diabetic Rats. Tropical Journal of Pharmaceutical Research 15(1):87.
Crossref

 

Kang JG, Park C (2012). Anti-Obesity Drugs: A Review about Their Effects and Safety. Diabetes and Metabolism Journal 36(1):13.
Crossref

 

Kanteev M, Bregman-Cohen A, Deri B, Shahar A, Adir N, Fishman A (2015). A crystal structure of 2-hydroxybiphenyl 3-monooxygenase with bound substrate provides insights into the enzymatic mechanism. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1854(12):1906-1913.
Crossref

 

Kim K, Maderna A, Schnute ME, Hegen M, Mohan S, Miyashiro J, Lin L, Li E, Keegan S, Lussier J, Wrocklage C, Nickerson-Nutter CL, Wittwer AJ, Soutter H, Caspers N, Han S, Kurumbail R, Dunussi-Joannopoulos K, Douhan J, Wissner A (2011). Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis. Bioorganic and Medicinal Chemistry Letters 21(21):6258-6263.
Crossref

 

Kim SH, Hong SH, Park YJ, Sung J, Suh W, Lee KW, Jung K, Lim C, Kim JH, Kim H, Park KS, Park SG (2019). MD001, a Novel Peroxisome Proliferator-activated Receptor α/γ Agonist, Improves Glucose and Lipid Metabolism. Scientific Report 9(1656):1-12.
Crossref

 

Van de Laar FA, Lucassen PL, Akkermans RP, Van de Lisdonk EH, Rutten GE, Van Weel C (2005). Alpha-glucosidase inhibitors for type 2 diabetes mellitus C. M. and E. D. Group (ed). Netherland: John Wiley & Sons, Ltd. 
Crossref

 

Lee JY, Jeong K, Shin S, Lee J, Kim Y (2012). Discovery of novel selective inhibitors of Staphylococcus aureus β-ketoacyl acyl carrier protein synthase III. European Journal of Medicinal Chemistry 47(1):261-269.
Crossref

 

Levy C, Minnis D, Derrick JP (2008). Dihydropteroate synthase from Streptococcus pneumoniae: structure, ligand recognition and mechanism of sulfonamide resistance. Biochemical Journal 412(2):379-388.
Crossref

 

Li H, Van Vranken S, Zhao Y, Li Z, Guo Y, Eisele L, Li Y (2005). Crystal structures of T cell receptor β chains related to rheumatoid arthritis. Protein Science 14(12):3025-3038.
Crossref

 

Lomenick B, Olsen RW, Huang J (2011). Identification of Direct Protein Targets of Small Molecules. ACS Chemical Biology 6(1):34-46.
Crossref

 

Lyons DS, Lieberman SA, Hampl J, Boniface JJ, Chien Y, Berg LJ, Davis MM (1996). A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5(1):53-61.
Crossref

 

Ma CI, Diraviyam K, Maier ME, Sept D, Sibley LD (2013). Synthetic Chondramide A Analogues Stabilize Filamentous Actin and Block Invasion by Toxoplasma gondii. Journal of Natural Products 76(9):1565-1572.
Crossref

 

Mata R, Reddy Nakkala J, Rani Sadras S (2015). Catalytic and biological activities of green silver nanoparticles synthesized from Plumeria alba (frangipani) flower extract. Materials Science and Engineering C 51:216-225.
Crossref

 

Matschinsky F, Porte Jr D (2010). Glucokinase activators (GKAs) promise a new pharmacotherapy for diabetics. F1000 Medicine Reports 5(June):1-5.
Crossref

 

Miner-Williams W (1980). Surfactant inhibition of cholesterol oxidase. Clinica Chimica Acta 101(1):77-84.
Crossref

 

Müller IB, Wu F, Bergmann B, Knöckel J, Walter RD, Gehring H, Wrenger C (2009). Poisoning Pyridoxal 5-Phosphate-Dependent Enzymes: A New Strategy to Target the Malaria Parasite Plasmodium falciparum A. Lewin (ed). PLoS ONE 4(2):e4406.
Crossref

 

Murugan V, Inamdar JA (1987). Organographic distribution, structure and ontogeny of lactifers in Plumeria alba Linn. Plant Science 97(1):25-31.

 

Ningsih DR, Zusfahair, Kartika D, Lestari IT (2017). Synthesis of Anti-Acne Ointment of Ethanol Extract of White Plumeria Leaves (Plumeria Alba L.). In IOP Conference Series: Materials Science and Engineering 172:1-9.
Crossref

 

Nurcahyo H, Purgiyanti (2017). Pemanfaatan Bunga Kamboja (Plumeria alba) Sebagai Aromaterapi. Jurnal Para Pemikir 6(1):121-123.

 

Patrick LG (2013). An Introduction to Medicinal Chemistry fifth. Intergovernmental Panel on Climate Change (ed). Cambridge: Cambridge University Press pp. 10-13.

 

Putra KC, Nugroho ES, Wisnumurti YK, Dewa SP, Jati BWP, Tiara R, Setyaningsih D, Hariono M (2019). In silico Study of Thioguanine Derivatives As Hemopexin Matrix Uji Aktivitas Turunan Thioguanine Terhadap Hemopexin Matrix Metalloproteinase9 (PEX-9 ) In silico 1(2):17-24.

 

Rahman H, Reddy VB, Ghosh S, Mistry SK, Pant G, Sibi G (2014). Antioxidant, Cytotoxic and Hypolipidemic Activities of Plumeria alba L. and Plumeria rubra L. American Journal of Life Sciences 2(6):11-15.
Crossref

 

Rattanapan J, Sichaem J, Tip-pyang S. (2012). Chemical constituents and antioxidant activity from the stems of Alyxia reinwardtii. Records of Natural Products 6(3):288-291.

 

Roussel A, Canaan S, Egloff M, Rivière M, Dupuis L, Verger R, Cambillau C (1999). Crystal Structure of Human Gastric Lipase and Model of Lysosomal Acid Lipase, Two Lipolytic Enzymes of Medical Interest. Journal of Biological Chemistry 274(24):16995-17002.
Crossref

 

Savvides SN, Scheiwein M, Böhme CC, Arteel GE, Karplus PA, Becker K, Schirmer RH (2002). Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite. Journal of Biological Chemistry 277(4):2779-2784.
Crossref

 

Scally SW, Petersen J, Law SC, Dudek NL, Nel HJ, Loh KL, Wijeyewickrema LC, Eckle SBG, Van Heemst J, Pike RN, McCluskey J, Toes RE, La Gruta NL, Purcell AW, Reid HH, Thomas R, Rossjohn J (2013). A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. The Journal of Experimental Medicine 210(12):2569-2582.
Crossref

 

Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT (2001). Crystal Structure of the Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Synthase III. Journal of Biological Chemistry 276(23):20516-20522.
Crossref

 

Shang J, Cai X, Zhao Y, Feng T, Luo X (2010). Pharmacological evaluation of Alstonia scholaris: Anti-tussive, anti-asthmatic and expectorant activities. Journal of Ethnopharmacology 129(3):293-298.
Crossref

 

Shinde PR, Patil PS, Bairagi VA (2014). Phytopharmacological Review of Plumeria species. Scholars Academic Journal of Pharmacy 3(2):217-227.

 

Shirai T, Hung VS, Morinaka K, Kobayashi T, Ito S (2008). Crystal structure of GH13 α-glucosidase GSJ from one of the deepest sea bacteria. Proteins: Structure, Function, and Bioinformatics 73(1):126-133.
Crossref

 

Siddiqui BS, Sultana R, Begum S, Zia A, Suria A (1997). Cardenolides from the Methanolic Extract of Nerium oleander Leaves Possessing Central Nervous System Depressant Activity in Mice. Journal of Natural Products 60(6):540-544.
Crossref

 

Sloan SA, Zimmerman JK, Sabat AM (2007). Phenology of Plumeria alba and its Herbivores in a Tropical Dry Forest. Biotropica 39(2):195-201.
Crossref

 

Sorci L, Pan Y, Eyobo Y, Rodionova I, Huang N, Kurnasov O, Zhong S, MacKerell AD, Zhang H, Osterman AL (2009). Targeting NAD Biosynthesis in Bacterial Pathogens: Structure-Based Development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD. Chemistry and Biology 16(8):849-861.
Crossref

 

Staudacher V, Djuika CF, Koduka J, Schlossarek S, Kopp J, Büchler M, Lanzer M, Deponte M (2015). Plasmodium falciparum antioxidant protein reveals a novel mechanism for balancing turnover and inactivation of peroxiredoxins. Free Radical Biology and Medicine 85:228-236.
Crossref

 

Strater N, Sherratt DJ, Colloms SD (1999). X-ray structure of aminopeptidase A from Escherichia coli and a model for the nucleoprotein complex in Xer site-specific recombination. The EMBO Journal 18(16):4513-4522.
Crossref

 

Sujarwo W, Keim AP (2017). Ethnobotanical Study of Traditional Building Materials from the Island of Bali, Indonesia. Economic Botany 71(3):224-240.
Crossref

 

Syakira MH, Brenda L (2010). Antibacterial Capacity of Plumeria alba Petals. International Journal of Pharmacological and Pharmaceutical Sciences 4(8):1203-1205.

 

Tan B, Shi H, Ji G, Xie J (2011). Effects of taraxerol and taraxerol acetate on cell cycle and apoptosis of human gastric epithelial cell line AGS. Journal of Chinese integrative medicine 9(6):638-42.
Crossref

 

Tang J, Li JG, Qi W, Qiu W, Li PS, Li B, Song B (2011). Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques. Cell Metabolism. 13(1):44-56.
Crossref

 

Tessou KZ, Lawson-Evi P, Metowogo K, Diallo A, Eklu-Gadegkeku K, Aklikokou K, Gbeassor M (2013). Acute and Sub-Acute Toxicity Studies of Plumeria alba Linn. (Apocynaceae) Hydroalcoholic Extract in Rat. International Journal of Biomedical Science 9(4):255-259.

 

Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM, Ignatev A, Lepper S, Frischknecht F, Sidén-Kiamos I, Sachse C, Kursula I (2014). Structural Differences Explain Diverse Functions of Plasmodium Actins. PLoS Pathogens 10(4):e1004091.
Crossref

 

Vellucci S V (2010). Cytokines, Behavior, and Affective Disorders. New Insights to Neuroimmune Biology. 1. ed. Cambridge: Elsevier Inc. 12:237-254
Crossref

 

Venable J, Ameriks M, Blevitt J, Thurmond R, Fung-Leung WP (2010). Phosphoinositide 3-Kinase Gamma (PI3Kγ) Inhibitors for the Treatment of Inflammation and Autoimmune Disease. Recent Patents on Inflammation and Allergy Drug Discovery 4(1):1-15.
Crossref

 

Verma S (2016). Multipurpose Ornamental Plant Plumeria rubra Linn (Apocynaceae). International Jounal of Scientific Research in Science and Tecnology 2(4):646-649.

 

Vijayalakshmi A, Ravichandiran V, Velraj M, Hemalatha S, Sudharani G, Jayakumari S (2011). Anti-anaphylactic and anti-inflammatory activities of a bioactive alkaloid from the root bark of Plumeria acutifolia Poir. Asian Pacific Journal of Tropical Biomedicine 1(5):401-405.
Crossref

 

Wadianur F, Hidayati L, Rahayu YC (2018). Effectiveness Of Cambodia White Flower Extract (Plumeria alba L.) As Denture Cleanser On The Growth Of Candida albicans In Base Material Of Artificial Teeth Nylon Thermoplastic (Valplast). Pustaka Kesehatan 6(1):161.
Crossref

 

Wang P, Read M, Sims PFG, Hyde JE (1997). Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Molecular Microbiology 23(5):979-986.
Crossref

 

Watt JM, Breyer-Brandwijk MG (1933). The Medicinal and Poisonous Plants of Southern Africa: Being an Account of their Medicinal Uses, Chemical Composition, Pharmacological Effects and Toxicology in Man and Animal. Nature 132(3331):336-336.
Crossref

 

Wiart C (2006). Medicinal Plants of Asia and the Pacific. London: CRC Press Taylor & Francis Group. 250 p.
Crossref

 

Winter VJ, Cameron A, Tranter R, Sessions RB, Brady RL (2003). Crystal structure of Plasmodium berghei lactate dehydrogenase indicates the unique structural differences of these enzymes are shared across the Plasmodium genus. Molecular and Biochemical Parasitology 131(1):1-10.
Crossref

 

Wrasiati LP, Wirawan IGP, Bagiada NA, Astawa INM (2011). Antioxidant capacity of frangipani (Plumeria alba) Powder Extract. Indonesian Journal of Biomedical Sciences 5(2):1-11.

 

Wu C (2014). An important player in brine shrimp lethality bioassay : The solvent. Journal of Advance Pharmaceutical tecnology and Research 5(1):57-58.

 

Yu M, Kumar TRS, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos J, Vilcheze C, Siedner M, Tsai JHC, Falkard B, Sidhu A bir S, Purcell LA, Gratraud P, Kremer L, Waters AP, Schiehser G, Jacobus DP, Janse CJ, Ager A, Jacobs WR, Sacchettini JC, Heussler V, Sinnis P, Fidock DA (2008). The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites. Cell Host and Microbe 4(6):567-578.
Crossref

 

Yu Y, Deck JA, Hunsaker LA, Deck LM, Royer RE, Goldberg E, Vander Jagt DL (2001). Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4. Biochemical Pharmacology 62(1):81-89.
Crossref

 

Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SR (2005). Crystal Structure of Murine 11β-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes. Biochemistry 44(18):6948-6957.
Crossref

 

Zhang L, Zhang CJ, Zhang D, Wen J, Zhao X, Li Y, Gao K (2014). An unusual indole alkaloid with anti-adenovirus and anti-HSV activities from Alstonia scholaris. Tetrahedron Letters 55(10):1815-1817.
Crossref