Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Vitamins C and E levels are enhanced by Azadirachta Indica leaves aqueous extract in paracetamol induced hepatoxicity in Wistar rats

Emmanuel Ikechukwu Nwobodo
  • Emmanuel Ikechukwu Nwobodo
  • Department of Biochemistry, Anambra State University Uli, Anambra State, Nigeria.
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Dennis C. Nwosu
  • Dennis C. Nwosu
  • Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria.
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Harrison U. Nwanjo
  • Harrison U. Nwanjo
  • Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria.
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Augustine C. Ihim
  • Augustine C. Ihim
  • Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
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John Kennedy Nnodim
  • John Kennedy Nnodim
  • Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria.
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Chinyere I. Nwobodo
  • Chinyere I. Nwobodo
  • Pharmacy Department, Enugu State University Teaching Hospital, Parklane, Enugu, Nigeria.
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Ukamaka C. Edwrad
  • Ukamaka C. Edwrad
  • Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria.
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  •  Received: 07 December 2015
  •  Accepted: 16 May 2016
  •  Published: 25 June 2016

References

Adeyemi OS, Bukola TO (2014). Lipid profile and oxidative stress markers in Wistar rats following oral and repeated exposure to fijk herbal mixture. J. Toxicol. 2014:876035.
Crossref

 

Alimba CG, Bakare AA, Aina OO (2012). Liver and kidney dysfunction in Wistar rats exposed to munincipal landfill leachate. Resour. Environ. 2(4):150-163.
Crossref

 
 

Bhanwra S, Singh P, Koshla P (2000). The effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol induced liver damage in rats. Indian J. Physiol Pharmacol. 44:4-69.

 
 

Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U (2002). Biological activities and Medicinal properties of neem (Azadirachta indica). Curr. Sci. 82(II):1336-1345.

 
 

Boeke SJ, Boersma MG, Alink GM, van Loon JJ, van Huis A, Dicke M, Rietjens IM (2004). Safety evaluation of neem (Azadirachta indica) derived pesticides. J. Ethnopharmacol. 94(1):25-41.
Crossref

 
 

Challopadhyay RR, Bandyopadhyay M (2005). Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract against paracetamol induced hepatic damage in rats. Part.III. Indian J. Pharmacol. 37(3):184-185.
Crossref

 
 

Essani NA, Fisher MA, Farhood A, Manning AM, Smith CW, Jaeschke H (1995). Cytokine-induced hepatic intercellular adhesion molecule-1 (ICAM-1) messenger RNA expression and its role in the pathology of murine endotoxin shock and acute liver failure. Hepatology 21:1632-1639.

 
 

Frie B, Stocker R, Ames BN (1988). Antioxidant defences and lipid peroxidation in human blood plasma. Proc. Nat. Acad. Sci. USA 85:9748-9752.
Crossref

 
 

Halliwell B, Glutteridge JMC (1989). (Eds.). Free Radicals in Biology and Medicine. 2ndedition. Oxford, UK: Clarendon Press.

 
 

Hazai E, Vereczkey L, Monostory K (2002). Reduction of toxic metabolites formation of acetaminophen. Broch. Biophys. Res. Ommun. 291(4):1089-1094.
Crossref

 
 

Ha HL, Shin HJ, Feitelson MA, Yu DY (2010). Oxidative stress and antioxidants in hepatic pathogenesis. World J. Gastroenterol. 16(48): 6035-6043.
Crossref

 
 

Hossain MA, Al-Toubi WAS, Weli AM, Al-Riyami QA, Al-Sabahi JN (2013). Identification and characterization of chemical compounds in different crude extracts from leaves of Omani neem. J. Taibah Univ. Sci. 7(4):181-188.
Crossref

 
 

Ihim AC, Nwosu DC, Nwanjo HU, Onyenekwe CC, Nnodim JK, Manafa PO, Okeke AC, Oluboye AO, Nwobodo EI, Nwadike C, Oze G (2013). Antilipid peroxidative and hypolipidemic potentials of Nauclea latifolia leaves extract on ciprofloxacin induced oxidative stress in rats. Asian J. Pharm. Biol. Res. 3(1):18-23.

 
 

King EJ, King PR (1954). Estimation of plasma phosphates by determination of hydrolyzed phenol with amino antipyrene. J. Chem. Pathol. 7:322-326.

 
 

Kutlu M, NaziroÄŸhu M, SimÅŸek, H, Yilmaz T, Sahap Kükner A (2005). Moderate exercise combined with dietary Vitamin C and E counteract oxidative stress in kidney and lens of streptozotocin - induced diabetic rats. Int. J. Vit. Nutr. Res. 75:71-80.
Crossref

 
 

Litch JT, Wilcoxon F (1959). Determination of acute toxicity tests. J. Pharmacol. Exp. Ther. 96:99-113.

 
 

Masalkar PD, Abhang SA (2005). Oxidative stress and antioxidant status in patients with alcoholic liver disease. Clin. Chim. Acta 355(1-2):61-65.
Crossref

 
 

Molavi B, Mehta JL (2004). Oxidative stress in cardiovascular disease: Molecular basis of its deleterious effects, its detection and therapeutic considerations. Curr. Opin. Cardiol. 19(5):488-493.
Crossref

 
 

Niki E (1991). Actions of ascorbic acid as a scavenger of active and stable oxygen species. Am. J. Clin. Nutr. 54:1119S-24S.

 
 

Nunomura A, Castellani R, Zhu X, Moreira PI, Perry G, Smith MA (2006). Involvement of oxidative stress in Alzheimer disease. J. Neuropathol. Exp. Neurol. 65(7):631-641.
Crossref

 
 

Nwanjo HU, Orjiako AO (2006). Effects of vitamins E and C on exercise-induced oxidative stress. Glob. J. Pure Appl. Sci. 12(2):199-202.
Crossref

 
 

Omaye ST, Turnbull JD, Sauberlich HE (1979). Selected methods for the determination of Ascorbic acid in animals cells, tissues and fluids. Methods Enzymol. 62:3-11.
Crossref

 
 

Pennington TD, Styles BT (1975). A generic monograph of the melicicea. Blumea 22:419-540.

 
 

Quaife ML, Scrimshaw NS, Lowry OH (1949). A micromethod for assay of totaltocopherols in blood serum. J. Biol. Chem. 180(3):1229-1235.

 
 

Rao GM, Sumita P, Roshni M, Ashtagimatt MN (2005). Plasma antioxidant vitamins and lipid peroxidation products in pregnancy induced hypertension. Indian J. Clin. Biochem. 20(1):198-200.
Crossref

 
 

Reitman S, Frankel S (1957). Colorimetric method for the determination of serum glutamate oxaloacetic transaminase and glutamate pyruvate transaminases. Am. J. Clin. Pathol. 28(1):56-63.
Crossref

 
 

Sen P, Medinata PK, Ray A (1992). Immunostimulant activities of A. indica. Indian J. Exp. Biol. 12:1170-1175.

 
 

Sharma P, Shankar S, Agarwal A, Singh R (2010). Variations in serum lipids and liver function markers in lindane exposed female Wistar rats: Attenuating effect of circumin, vitamin C and vitamin E. Asian J. Exp. Biol. Sci. 1(2):440-444.

 
 

Thomson G (2013). Review: Nrf2, a multi organ protector. Available at: 

View

 
 

Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007). Free radicals and antioxidants in normal physiological functions and human diseases. Int. J. Biochem. Cell Biol. 39(1):44-84.
Crossref

 
 

Veinbergs I, Mallory M, Sagara Y, Masliah E (2000). Vitamin E supplementation prevents spatial learning deficit and dendritic alteration in aged apolipoprotein E deficient mice. Eur. J. Neurosci. 12(12):4541-4546.

 
 

Willcox JK, Ash SL, Catignani GL (2004). Antioxidants and prevention of chronic diseases. Crit. Rev. Food Sci. Nutr. 44(4):275-295.
Crossref

 
 

Zaidi SM, Al-Qirim TM, Banu N (2005). Effects of antioxidant vitamins on glutathione depletion and lipid peroxidation induced by restraint stress in the rat liver. Drugs R D. 6(3):157-65.
Crossref