Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

Myrothamnus flabellifolius attenuates streptozotocin-high energy diet-induced type 2 diabetes in male sprague dawley rats

Tebogo Elvis Kwape
  • Tebogo Elvis Kwape
  • Department of Biological Sciences and Biotechnology, Faculty of Sciences, Botswana International University of Science and Technology, Palapye, Botswana.
  • Google Scholar
Padmaja Chaturvedi
  • Padmaja Chaturvedi
  • Department of Biological Sciences, Faculty of Sciences, University of Botswana, Gaborone, Botswana.
  • Google Scholar
Goabaone Gaobotse
  • Goabaone Gaobotse
  • Department of Biological Sciences and Biotechnology, Faculty of Sciences, Botswana International University of Science and Technology, Palapye, Botswana.
  • Google Scholar
Kabo Masisi
  • Kabo Masisi
  • Department of Biological Sciences and Biotechnology, Faculty of Sciences, Botswana International University of Science and Technology, Palapye, Botswana.
  • Google Scholar
Keagile Bati
  • Keagile Bati
  • Department of Biological Sciences and Biotechnology, Faculty of Sciences, Botswana International University of Science and Technology, Palapye, Botswana.
  • Google Scholar
Runner Majinda
  • Runner Majinda
  • Department of Chemistry, Faculty of Sciences, University of Botswana, Gaborone, Botswana.
  • Google Scholar


  •  Received: 18 August 2020
  •  Accepted: 09 October 2020
  •  Published: 31 December 2020

References

Abu-Saad K, Murad H, Barid R, Olmer L, Ziv A, Younis-Zeidan N, Kaufman-Shriqui V, Gillon-Keren M, Rigler S, Berchenko Y, Kalter-Leibovici O (2019). Development and Efficacy of an Electronic, Culturally Adapted Lifestyle Counseling Tool for Improving Diabetes-Related Dietary Knowledge: Randomized Controlled Trial Among Ethnic Minority Adults with Type 2 Diabetes Mellitus. Journal of Medical Internet Research 21(10):e13674.
Crossref

 

Asmat U, Khan A, Ismail KI (2016). Diabetes mellitus and oxidative stress-A concise review. Saudi Pharmaceutical Journal 24:547-553.
Crossref

 

Axelsson AS, Mahdi T, Nenonen HA, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe TM, Millstein J, Yang X, Zhang B (2017). Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes. Nature Communications 8:15652.
Crossref

 

Bahmani M, Golshahi H, Saki K, Rafieian-Kopaei M, Delfan B, Mohammadi T (2014). Medicinal plants and secondary metabolites for diabetes mellitus control. Asian Pacific Journal of Tropical Diseases 4:S687-S692.
Crossref

 

Bartelt A, John C, Schaltenberg N, Berbée JFP, Worthmann A, Cherradi ML, Heeren J (2017). Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport. Nature Communications 8:15010.
Crossref

 

Besler C, Lu TF (2012). Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease. EMBO Molecular Medicine 4:251-268.
Crossref

 

Benhaddou-Andaloussi A, Martineau L, Vuong T, Meddah B, Madiraju P, Settaf A, Haddad PS (2011). The in vivo antidiabetic activity of Nigella sativa is mediated through activation of the AMPK pathway and increased muscle GLUT4 content. Evidence Based Complementary and Alternative Medicine 2011:1-9.
Crossref

 

Cavero-Redondo I, Peleteiro B, Álvarez-bueno C, Rodriguez-artalejo F, Martínez-vizcaíno V (2017). Glycated haemoglobin A1c as a risk factor of cardiovascular outcomes and all-cause mortality in diabetic and non- diabetic populations: a systematic review and meta-analysis. BMJ Open 7:1-11.
Crossref

 

Cheikyoussef A, Summers RA, Kahaka G (2015). Qualitative and quantitative analysis of phytochemical compounds in Namibian Myrothamnus flabellifolius. International Science and Technology Journal of Namibia 5:71-83.

 

De Luca V, Salim V, Atsumi SM, Yu F (2012). Mining the biodiversity of plants: a revolution in the making. Science 336:1658-1661.
Crossref

 

Ding W, Zhang Q, Dong Y, Ding N, Huang H, Zhu X (2016). Adiponectin protects the rat's liver against chronic intermittent hypoxia induced injury through AMP-activated protein kinase pathway. Nature Scientific Reports 6:34151.
Crossref

 

Erhabor JO, Komakech R, Kang Y, Tang M, Matsabisa MG (2020). Ethnopharmacological importance and medical applications of Myrothamnus flabellifolius Welw. (Myrothamnaceae)-A review. Journal of Ethnopharmacology 252(2020):112576.
Crossref

 

Faselis C, Katsimardou A, Imprialos K, Deligkaris P, Dimitriadis K (2020). Microvascular Complications of Type 2 Diabetes Mellitus. Current Vascular Pharmacology, 18(2):117-124.
Crossref

 

Gandhi GR, Sasikumar P (2012). Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin-induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine 2:281-286.
Crossref

 

Gruzdeva O, Borodkina D (2019). Leptin resistance: underlying mechanisms and diagnosis. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 12:191-198.
Crossref

 

Guo S, Meng XW, Yang XS, Liu XF, Ou-Yang CH, Liu C (2018). Curcumin administration suppresses collagen synthesis in the hearts of rats with experimental diabetes. Acta Pharmacologica Sinica 39(2):195-204.
Crossref

 

Gupta RC, Chang D, Nammi S, Bensoussan A, Bilinski K, Roufogalis BD (2017). Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications. Diabetology and Metabolic Syndrome 9:59.
Crossref

 

International Diabetes Federation (IDF) (2019). Diabetes Atlas, 9th Edn. Brussels, International Diabetes Federation. [Accessed February 13, 2020].

 

Kahn SE, Cooper ME, Del Prato S (2014). Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. The Lancet 383(9922):1068-1083.
Crossref

 

Kim B, Kim M, Hyun C (2017). Syringin attenuates insulin resistance via adiponectin-mediated suppression of low-grade chronic inflammation and ER stress in high- fat diet-fed mice. Biochemical and Biophysical Research Communications 488(1):40-45.
Crossref

 

King AJ (2012). The use of animal models in diabetes research. British Journal of Pharmacology 166(3):877-894.
Crossref

 

Kuo Y, Lin C, Shih C, Yang C (2016). Antcin K, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects via Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in Muscles. Evidence-based Complementary and Alternative Medicine 2016:4867092.
Crossref

 

Kwape TE, Majinda RRT, Chaturvedi P (2016). Antioxidant and antidiabetic potential of Myrothamnus flabellifolius found in Botswana. Cogent Biology 2:1275403.
Crossref

 

Mohan Y, Jesuthankaraj GN, Thangavelu NR (2013). Antidiabetic and Antioxidant Properties of Triticum aestivum in Streptozotocin-Induced Diabetic Rats. Advances in Pharmacological and Pharmaceutical Sciences 2013:716073.
Crossref

 

Molefe-Khamanga DM, Mooketsi INA, Matsabisa MG, Kensley RM (2012). Qualitative phytochemical studies of solvent extracts from Myrothamnus flabellifolius. International Journal of Medicinal Plants Research 1:155.

 

Motlhanka DMT, Mathapa G (2011). Antioxidant activities of crude extracts from medicinal plants used by diabetic patients in Eastern Botswana. Journal of Medicinal Plants Research 6:5460-5463.

 

Rehman K, Akash MSH (2017). Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked? Journal of Cellular Biochemistry 118(11):3577-3585.
Crossref

 

Safhi MM, Alam MF, Sivakumar SM, Anwer T (2019). Hepatoprotective Potential of Sargassum muticum against STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway. Analytical Cellular Pathology 2019:7958701.
Crossref

 

Setshogo MP, Mbereki CM (2011). Floristic Diversity and uses of medicinal plants sold by street vendors in Gaborone, Botswana. African Journal of Plant Science and Biotechnology 5:69-74.

 

Singh S, Singh V, Yadav S, Singh R, Baksh H, Singh BK, Pandey R (2018). Medicinal plant: an emergence of natural medicine for human. International Journal of Engineering, Science and Advanced Research 4(2):28-34.

 

Storey BC, Staplin N, Haynes R, Reith C, Emberson J, Herrington WG, Fellstro B (2018). Lowering LDL cholesterol reduces cardiovascular risk independently of presence of inflammation. Kidney International 93:1000-1007.
Crossref

 

Takaguri A, Inoue S, Kubo T, Satoh K (2016). AMPK activation by prolonged stimulation with interleukin-1 b contributes to the promotion of GLUT4 translocation in skeletal muscle cells. Cell Biology International 40:1204-1211.
Crossref

 

Tao C, Sifuentes A, Holland WL (2014). Regulation of Glucose and Lipid Homeostasis by Adiponectin: Effects on Hepatocytes, Pancreatic β Cells and Adipocytes. Best Practice and Research: Clinical Endocrinology and Metabolism 28(1):43-58.
Crossref

 

Wang ZV, Scherer PE (2016). Adiponectin, the past two decades. Journal of Molecular Cell Biology 8(2):93-100.
Crossref

 

Wang Y, Wen L, Zhou S, Zhang Y, Wang X, He Y, Davie A, Broadbent S (2018). Effects of four weeks intermittent hypoxia intervention on glucose homeostasis, insulin sensitivity, GLUT4 translocation, insulin receptor phosphorylation, and Akt activity in skeletal muscle of obese mice with type 2 diabetes. Plos ONE 13(9):e0203551.
Crossref

 

Wilson RD, Islam MS (2012). Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes. Pharmacology Reports 64:129-139.
Crossref