June 2018

Evaluation of Procavia capensis hyraceum used in traditional medicine for modulation of mutagen-induced genotoxicity

Hyraceum (HM) is used in traditional medicine in Southern Africa. Three concentrations of HM (mg/ml in distilled water) (0.0156, 0.03125 and 0.0625) were assessed for cytotoxicity (CT), genotoxicity (GT) and modulation of cyclophosphamide (CP)- and ethyl methanesulfonate (EMS)-induced GT using the Allium cepa assay following 24 h treatment.  CP (1.00 mg/ml) and EMS (0.0375 mg/ml) were not cytotoxic but genotoxic....

Author(s): Asita Okorie Asita, Thabang Rants’o, Sibusisiwe Magama and Matsepo Taole  

June 2018

Acute toxicity evaluation of ethanol extract of red algae, Osmundaria obtusiloba, in BALB/c mice

The genus Osmundaria (Rhodophyta, Ceramilaes, Rhodomelaceae) comprises tropical and temperate regions red marine seaweeds species. Osmundaria obtusiloba is distributed from the northeastern coast of Brazil to the state of Rio de Janeiro. Studies with ethanol extract of red seaweed O. obtusiloba showed the antiviral potential of this alga. Hence, this study examined in BALB/c mice the acute toxicity after oral...

Author(s): Caroline de Souza Barros, Max Willian Lisboa Gomes, Rafaela dos Santos Pereira Gomes, Vanessa Melchiades, Caio Cesar Richter Nogueira, Claudio César Cirne-Santos, Valeria Garrido, Carla Eponina Carvalho Pinto, Valeria Laneuville Teixeira and Izabel Christina Nunes de Palmer Paixão