Journal of
Metabolomics and Systems Biology

  • Abbreviation: J. Metabolomics Syst. Biol.
  • Language: English
  • ISSN: 2805-4210
  • DOI: 10.5897/JMSB
  • Start Year: 2010
  • Published Articles: 9

Full Length Research Paper

1H NMR urine metabolomics is an effective prognostic indicator in acute spinal cord injury (ASCI): A prospective case-control study

Alka Singh
  • Alka Singh
  • Department of Orthopaedic Surgery, King George’s Medical University (KGMU), Shahmina Road, Chowk, Lucknow, Uttar Pradesh, India.
  • Google Scholar
Rajeshwar Nath Srivastava
  • Rajeshwar Nath Srivastava
  • Department of Orthopaedic Surgery, King George’s Medical University (KGMU), Shahmina Road, Chowk, Lucknow, Uttar Pradesh, India.
  • Google Scholar
Tanushri Chatterji
  • Tanushri Chatterji
  • Department of Microbiology, Dr. Ram Manohar Lohia Institute of Medical Sciences (RMLIMS), Vibhuti Khand, Gomti Nagar, Lucknow, Uttar Pradesh, India.
  • Google Scholar
Suruchi Singh
  • Suruchi Singh
  • Centre of Biomedical Research, formerly Centre of Biomedical Magnetic Resonance (CBMR), Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Rae Bareli Road, Lucknow, Uttar Pradesh, India.
  • Google Scholar
Lavini Raj
  • Lavini Raj
  • Department of Orthopaedic Surgery, King George’s Medical University (KGMU), Shahmina Road, Chowk, Lucknow, Uttar Pradesh, India.
  • Google Scholar
Abbas Ali Mahdi
  • Abbas Ali Mahdi
  • Department of Biochemistry, King George’s Medical University (KGMU), Shahmina Road, Chowk, Lucknow, Uttar Pradesh, India.
  • Google Scholar
Ravindra Kumar Garg
  • Ravindra Kumar Garg
  • Department of Neurology, King George’s Medical University (KGMU), Shahmina Road, Chowk, Lucknow, Uttar Pradesh, India.
  • Google Scholar
Raja Roy
  • Raja Roy
  • Centre of Biomedical Research, formerly Centre of Biomedical Magnetic Resonance (CBMR), Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Rae Bareli Road, Lucknow, Uttar Pradesh, India.
  • Google Scholar


  •  Received: 15 January 2020
  •  Accepted: 26 August 2020
  •  Published: 31 October 2020

References

An M, Gao Y (2015). Urinary biomarkers of brain diseases. Genomics, Proteomics and Bioinformatics13(6):345-354.
Crossref

 

Andres RH, Ducray AD, Schlattner U, Wallimann T, Widmer HR (2008). Functions and effects of creatine in the central nervous system. Brain Research Bulletin 76(4):329-343.
Crossref

 

Basile DP, Anderson MD, Sutton TA (2012). Pathophysiology of acute kidney injury. Comprehensive Physiology 2(2):1303.
Crossref

 

Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, Nicholson JK (2007). Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum, and tissue extracts. Nature Protocols 2(11):2692.
Crossref

 

Chatterji T, Singh S, Sen M, Singh AK, Maurya PK, Husain N, Srivastava JK, Mandal SK, Roy R (2016). Comprehensive 1H NMR metabolic profiling of body fluids for differentiation of meningitis in adults. Metabolomics 12(8):130.
Crossref

 

Chen C-S, Huang C-H, Shih S-L (2015). Biomechanical evaluation of a new pedicle screw-based posterior dynamic stabilization device (Awesome Rod System)-a finite element analysis. BMC Musculoskeletal Disorders 16(1):81.
Crossref

 

Chevalier AC, Rosenberger TA (2017). Increasing acetyl‐coa metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis. Journal of Neurochemistry 141(5):721-737.
Crossref

 

Choi H, Schmidbauer N, Sundell J, Hasselgren M, Spengler J, Bornehag CG (2010). Common household chemicals and allergy risks in pre-school age children. PloS ONE 5(10):e13423.
Crossref

 

Clark Jr LC, Thompson H (1949).Determination of creatine and creatinine in urine. Analytical Chemistry 21(10):1218-1221.
Crossref

 

Da Silva L, Godejohann M, Martin Fo-PJ, Collino S, Bürkle A, Moreno- Villanueva M (2013). High-resolution quantitative metabolome analysis of urine by automated flow injection NMR. Analytical Chemistry 85(12):5801-5809.
Crossref

 

Daniel W (1999). Biostatistics: A Foundation for Analysis in the Health Sciences, 7th edR Wiley. New York.

 

Elmelund M, Oturai P, Toson B, Biering-Sørensen F (2016). Forty-five-year follow-up on the renal function after spinal cord injury. Spinal Cord 54(6):445.
Crossref

 

Emwas AH, Luchinat C, Turano P, Tenori L, Roy R, Salek RM, Ryan D, Merzaban JS, Kaddurah-Daouk R, Zeri AC, Nagana Gowda GA (2015). Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review. Metabolomics 11(4):872-94.
Crossref

 

Emwas AH, Roy R, McKay RT, Ryan D, Brennan L, Tenori L, Luchinat C, Gao X, Zeri AC, Gowda GA (2016). Recommendations and standardization of biomarker quantification using NMR-based metabolomics with particular focus on urinary analysis. Journal of proteome research 15(2):360-373.
Crossref

 

Figueroa JD, Cordero K, llán MS, De Leon M (2013). Dietary omega-3 polyunsaturated fatty acids improve the neurolipidome and restore the DHA status while promoting functional recovery after experimental spinal cord injury. Journal of Neurotrauma 30(10):853-68.
Crossref

 

Gao Y (2013).Urine-an untapped goldmine for biomarker discovery. Science China Life Sciences 56(12):1145-1146.
Crossref

 

Gao X, Lin SH, Ren F, Li JT, Chen JJ, Yao CB, Wang Y (2016). Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nature Communications 7(1):1-14.
Crossref

 

Kaur P, Sharma S (2018). Recent advances in pathophysiology of traumatic brain injury.Current neuropharmacology 16(8):1224-1238.
Crossref

 

Kazubek-Zemke M, Rybka J, Marchewka Z, Rybka W, Pawlik K, DÅ‚ugosz A (2014). Preliminary study on application of urine amino acids profiling for monitoring of renal tubular injury using GLC-MS. Advances in Hygiene and Experimental Medicine/Postepy Higieny i Medycyny Doswiadczalnej.;68.
Crossref

 

Liu Y, Canovas R, Crespo GA, Cuartero M (2020). Thin-Layer Potentiometry for Creatinine Detection in Undiluted Human Urine Using Ion-Exchange Membranes as Barriers for Charged Interferences. Analytical Chemistry 92(4):3315-3323.
Crossref

 

Nägeli M, Fasshauer M, Sommerfeld J, Fendel A, Brandi G, Stover JF (2014). Prolonged continuous intravenous infusion of the dipeptide L-alanine-L-glutamine significantly increases plasma glutamine and alanine without elevating brain glutamate in patients with severe traumatic brain injury. Critical Care 18(4):R139.
Crossref

 

Nandoe Tewarie RS, Hurtado A, Bartels RH, Grotenhuis A, Oudega M (2009). Stem cell-based therapies for spinal cord injury. The Journal of Spinal Cord Medicine 32(2):105-114.
Crossref

 

Peng J, Zeng J, Cai B, Yang H, Cohen MJ, Chen W, Sun MW, Lu CD, Jiang H (2014). Establishment of quantitative severity evaluation model for spinal cord injury by metabolomic fingerprinting. PloS ONE 9(4):e93736.
Crossref

 

Piantoni P, Allen MS (2015). Evaluation of propylene glycol and glycerol infusions as treatments for ketosis in dairy cows. Journal of Dairy Science 98(8):5429-5439.
Crossref

 

Qian J, Herrera JJ, Narayana PA (2010). Neuronal and axonal degeneration in experimental spinal cord injury: in vivo proton magnetic resonance spectroscopy and histology. Journal of Neurotrauma 27(3):599-610.
Crossref

 

Roberts TT, Leonard GR, Cepela DJ (2017). Classifications in brief: American spinal injury association (ASIA) impairment scale. Clinical Orthopaedics and Related Research 475(5):1499-1504.
Crossref

 

Sahlin K (2014). Muscle energetics during explosive activities and potential effects of nutrition and training. Sports Medicine 44(2):167-173.
Crossref

 

Schuld C, Franz S, Brüggemann K, Heutehaus L, Weidner N, Kirshblum SC, Rupp R (2016). International standards for neurological classification of spinal cord injury: impact of the revised worksheet (revision 02/13) on classification performance. The Journal of Spinal Cord Medicine 39(5):504-512.
Crossref

 

ÅžimÅŸek T, ÅžimÅŸek HU, Cantürk NZ (2014) Response to trauma and metabolic changes: posttraumatic metabolism. Turkish Journal of Surgery/Ulusal Cerrahi Dergisi 30(3):153.
Crossref

 

Singh A, Srivastava RN, Agrahari A, Singh S, Raj S, Chatterji T, Mahdi AA, Garg RK, Roy R (2018).Proton NMR based serum metabolic profile correlates with the neurological recovery in treated acute spinal cord injury (ASCI) subjects: A pilot study. Clinica Chimica Acta 480:150-60.
Crossref

 

Speth P, Vree T, Neilen N, Newell D, Gore M (1987). Propylene glycol pharmacokinetics and effects after intravenous infusion in humans. Therapeutic Drug Monitoring 9(3):255-258.
Crossref

 

Srivastava R, Agrahari MAK, Chandra DT, Raj S (2015). A closed, safe, and cost-effective alternative algorithm of isolation of bone marrow-derived mononuclear cells. Journal of international Academic Research for Multidisciplinary 3(1):1-11.

 

Srivastava R, Gopal SC, Chandra T, Chandra A, Singh A, Agrahari AK (2015). Role of Surgery, Omentoplasty and Autologous Bone Marrow-Derived Mononuclear Cells Infusion on Clinical Outcomes After Spinal Cord Injury-A Randomized Controlled Trial. International Journal of Health Sciences and Research 5(3):82-91.

 

Srivastava RN, Singh A, Garg RK, Agarwal A, Raj S (2015). Epidemiology of Traumatic Spinal Cord Injury: A SAARC Perspective. International Journal of Molecular Biology and Biochemistry 3(1):9-22.

 

Van De Poll MC, Soeters PB, Deutz NE, Fearon KC, Dejong CH (2004) Renal metabolism of amino acids: its role in interorgan amino acid exchange. The American journal of Clinical Nutrition 79(2):185-97.
Crossref

 

Varma AK, Das A, Wallace G, Barry J, Vertegel AA, Ray SK, Banik NL (2013).Spinal cord injury: a review of current therapy, future treatments, and basic science frontiers. Neurochemical Research 38(5):895-905.
Crossref

 

Wiedeman AM, Barr SI, Green TJ, Xu Z, Innis SM, Kitts DD (2018). Dietary choline intake: current state of knowledge across the life cycle. Nutrients 10(10):1513.
Crossref

 

Wu J, Gao Y (2015). Physiological conditions can be reflected in the human urine proteome and metabolome. Expert review of proteomics 12(6):623-36.
Crossref

 

Wu Y, Streijger F, Wang Y, Lin G, Christie S, Mac-Thiong JM, Parent S, Bailey CS, Paquette S, Boyd MC, Ailon T (2016). Parallel metabolomic profiling of cerebrospinal fluid and serum for identifying biomarkers of injury severity after acute human spinal cord injury. Scientific Reports 6:38718.
Crossref

 

Xu J, Pan T, Qi X, Tan R, Wang X, Liu Z, Tao Z, Qu H, Zhang Y, Chen H, Wang Y (2020). Increased mortality of acute respiratory distress syndrome was associated with high levels of plasma phenylalanine. Respiratory Research 21:1-3.
Crossref