November 2011

The beneficial effects of extracts of Hibiscus sabdariffa calyces in alloxan-diabetic rats: Reduction of free-radical load and enhancement of antioxidant status

This study evaluates the effects of aqueous and ethanolic extracts of Hibiscus sabdariffacalyces on the in vitro and in vivo antioxidant activities in alloxan induced diabetic rats. Both the aqueous and ethanolic extracts showed marked antioxidant activity in oleic acid systems of ferric thiocyanate and thiobarbituric acid (TBA). They also exhibited 1, 1-diphenyl-1-picrylhydrazine (DPPH)...

Author(s): Sini J. M, Umar I. A., and Inuwa, H.M

November 2011

Antiplasmodial, analgesic and anti-inflammatory effects of crude Guiera senegalensis Gmel (Combretaceae) leaf extracts in mice infected with Plasmodium berghei

Guiera senegalensis is acclaimed as a common herbal antipyretic and antimalarial among some tribal groups in northern Nigeria. Leaf extracts of the plant were thus tested for antiplasmodial, analgesic and anti-inflammatory effects in vivo. Results indicated the safe dose of extracts as 600 mg/kg body weight of mice with LD50 of 1100 mg/kg bw. Only the methanolic fraction had antiplasmodial effect...

Author(s): Ali A. Jigam, Helmina O. Akanya, Bukar E. N. Dauda  and Emmanuel O. Ogbadoyi