Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009

JPP Articles in press


Article in Press

Sickle cell disease (SCD) in Nigeria is traditionally treated using herbs by Traditional Medical Practitioners (TMP). One of the herbs commonly used is Khaya, which is widely distributed in Africa, and three species exist in Nigeria. These are Khaya senegalensis A. Juss (KS), K. grandifoliola (WELW) CDC (KG) and K. ivorensis A. Chev. (KI). It was earlier discovered that K. senegalensis stem bark possessed anti-sickling...

Author(s):Ololade Adesomi Oyedapo., Mojisola Christanah Cyril-Olutayo., Joseph Morounfolu Agbedahunsi Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Nigeria Corresponding authors’ e-mail: [email protected], [email protected], [email protected] Tel.: + , + , +

Pharmacognostic and Anti-Inflammatory Studies of the Stem Bark of Pseudocedrela kotschyi Scheinf Harms (Meliaceae)

Article in Press

The aim of this study was to provide useful diagnostic parameters for the standardization of the plant and also to scientifically validate its acclaimed traditional use. Detailed macroscopy and microscopy studies were carried out using standard methods. Anti-inflammatory activity of the methanol crude extract was investigated using the egg-albumin induced oedema test. The stem bark has bitter taste, rough texture, brittle...

Author(s):Dalen Gwatau Dafam, Hajara Ibrahim, Rifkatu Turaki Manasseh, Temitayo Lucia Ohemu, Tongret Datok, Paul Nbegde Olotu , Victoria Akpidi Okwori, Falang Dadul Kakjing, and Njamas Ilyas.

Chemical composition and larvicidal activity on Anopheles gambiae s.l. of essential oils of six (6) aromatic plants of the Niger biodiversity

Article in Press

Synthetic insecticides such as organochlorines, carbamates, organophosphates or pyrethroids, used in the preventive fight against malaria, can be the cause of numerous cases of resistance in mosquitoes. Thus, the use of natural molecules with biodegradable insecticide or insect repellent properties and therefore more respectful of the environment and the ecosystem, could be an alternative to the use of synthetic...

Author(s):Issoufou YOLIDJE, Djibo ALFA KEITA, Idrissa MOUSSA, Jean-Luc PIRAT,

Phytochemical characterization and evaluation of the antisalmonella activity of leaf extracts of Telfairia occidentalis Hook.f. (Cucurbitaceae) on Salmonella typhii cell culture.

Article in Press

Typhoid fever commonly called typhoid is a bacterial infection caused by Salmonella typhi. Treatment is by the use of antibiotics which presents other challenges such as drug resistance, high cost of medication and less accessibility to the rural population. The aim and objective of this research was to identify the bioactive metabolites of the leaf of T. occidentalis, determine the antimicrobial activities.on Salmonella...

Author(s):Tamanji VL, Tembe EAF, Mbong GA, Bayaga H, Njinkio BN, Fonmboh DJ, Tchadji MV, Moody JO, Gonsu HK, Fokunang CN Department of Pharmacognosy, Pan African Institute of Life and Earth Sciences (PAULESI), University of Ibadan, Nigeria. Department of Pharmacotoxicology & Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé , Cameroon. Department of PDepartment of Plant Science, Faculty of Science, University of Dschang, Cameroon. Department of Pharmaco

Neuropharmacological evaluation with phytochemical screening in different parts of Acampe papillosa (Lindl.) Lindl. on Swiss albino mice

Article in Press

Phytochemical screening of fifteen secondary metabolites and neuropharmacological activity including cytotoxic, analgesic and anxiolytic or CNS depressant properties of Acampe papillosa (Lindl.) Lindl, an epiphytic medicinally important orchid species have been conducted to evaluate the medicinal potentiality for neurological activity. Secondary metabolites profiling include alkaloids, anthroquinone, coumarin, cardiac...

Author(s):Mohammed Mozammel Hoque, Md. Abul Kashem, Tahnia Basher

Cytoprotective effect of Arrabidaea chica Verlot extract associated with a fraction enriched with geranylgeraniol from Bixa orellana L. on epithelial cells treated with bisphosphonate

Article in Press

Bisphosphonates are drugs widely used to treat bone disorders such as osteoporosis and bone metastases. Despite their clinical importance, the long-term use of bisphosphonates is linked to the onset of medication-related osteonecrosis of the jaw (MRONJ). This study aimed to assess in vitro cytoprotective effects of Arrabidaea chica Verlot extract, at 1 and 5 µg mL-1, associated with a fraction enriched with geranylgeraniol...

Author(s):Rogério José Machado Júnior¹; Júlia C. Camilli², Rosanna Tarkany Basting, Patrícia Maria Wiziacki Zago³, Ilza Maria de Oliveira Sousa, Ana Lúcia T.G. Ruiz², Paulo Roberto Nogueira Carvalho, João Ernesto de Carvalho, Sara T. O. Saad, Mary Ann Foglio²

Laurus nobilis leaves extract protects against high fat diet-induced type 2 Diabetes in rats

Article in Press

Laurus nobilis, commonly known as bay, is used in folk medicine as a remedy for many ailments. The present study investigates the protective effect of L. nobilis leaves extract against high fat diet-induced type 2 diabetes in rats. Animals were divided into group 1 (control), groups 2, 3, and 4 (bay leaves aqueous (AQ) extracts; 50, 100, and 250 mg/kg of body weight respectively), and groups 5, 6, and 7 (bay leaves...

Author(s):Costantine F Daher, Robin I Taleb, Mohamad A Mroueh, Bilal Nehmeh, Hachem Araji, Rawan H Chakas, Aimee M Daccache, Kamar H Eid, Maria K El Khoury, Pamela F El Hayek, Hala T Faddoul, Elio Junior Feghali, Ahmad G Ghanem, Tony P Haydar, Abir R Jammoul, Sula H Nasra, Nouhad Saade, Donna G Tahan, Joey C. Daher, Esther Tannoury, Wassim N Shebaby

Quality control standardization and evaluation of the anti-inflammatory and antipyretic effects of the leaves and stem bark of Amphimas pterocarpoides harms (Leguminosae)

Article in Press

Amphimas pterocarpoides is used traditionally for the treatment of oedema, infections, malaria and skin diseases. This study described pharmacognostic and physicochemical parameters of the leaf and stem bark. The carrageenan-induced foot oedema and the baker’s yeast-induced pyrexia were used to assess the anti-inflammatory and antipyretic activities respectively. The leaf of A. pterocarpoides is oddly pinnate compound,...

Author(s):George Adjei-Hinneh, Gustav Komlaga,Evelyn Asante-Kwatia and Abraham Yeboah Mensah

In vitro Micropropagation and Biological Activities of Astragalus fruticosus Forssk.

Article in Press

An efficient micropropagation protocol was developed for the rare, wild Egyptian Astragalus fruticosus Forssk. plant. Seed coat scratching was very effective for getting high frequency of seed germination (100%). Murashige and Skoog (MS) medium fortified with different concentrations of N6-benzylaminopurine (BAP), kinetin (Kn) and thidiazuron (TDZ) either singly or in combination with auxins as 2, 4-Dichlorophenoxyacetic...

Author(s):Wafaa Ismaeil, Rawia Zayed and Ashraf. El-Sayed

Spermicidal and Antioxidant Activities of Ethanolic Leaf Extract of Solanum macrocarpon L. (African Eggplant) in Rattus norvegicus model

Article in Press

Phytochemical screening reveals many therapeutic potentials. This study was designed to evaluate the in vitro spermicidal (IVS) and serum antioxidant (SA) activities of ethanolic leaf extracts of Solanum macrocarpon (ELESM) in albino rats. The IVS activity was investigated using 2.5, 5 and 10 mg/ml of ELESM at 1, 5 and 10 minutes’ intervals. Thirty 10-12 weeks old male albino rats randomly assigned to six groups (A-F,...

Author(s):EZECHUKWU Chiemekam Samuel, MBEGBU Edmund Chidiebere, MGBENKA Bernard Obialo, ONOJA Samuel Okwudili, ODO Rita Ifeoma

Green Synthesis of Silver Nanoparticles through Reduction with Euphorbia nivulia Buch.-Ham., stem bark extract: Characterization and Antimicrobial Activity

Article in Press

Nanoparticles, because of their diversified applications in the field of modern medicine gained lot of importance thrust area. In the present investigation, synthesis and characterization of Silver nanoparticles (AgNPs) and their antimicrobial effect on certain pathogenic bacteria were studied. AgNPs were prepared by green synthesis process using stem extract of Euphorbia nivulia, from 1mM AgNO3 solution. The color...

Author(s):Naidu Sarojini Devi, Y. Padma and R.R. Venkata Raju

Screening of Potential Antioxidant with Inhibition of Free Radicals from the Extract Seluang Belum Roots (Luvunga sarmentosa (Blume) Kurz.) by ABTS Assay

Article in Press

An unhealthy lifestyle will usually cause free radical compounds that are reactive against cells and tissues of the body. Therefore free radical reactions in the body can be muted with the use of antioxidants that can help protect the body from free radical attack and resist its negative impact. The synthetic antioxidants such as BHA and BHT can cause damage to the liver and carcinogenic. Some scientific studies around the...

Author(s):Elsa Trinovita

Comparative studies on bioactive constituents of methanol extract of Picralima nitida : A medicinal plant frequently used in South-eastern Nigerian folk medicine

Article in Press

Picralima nitida is a medicinal plant of the family Apocynaceae, frequently used in South- eastern Nigerian traditional medicine for its therapeutic properties. This study is a comparative evaluation on the chemical constituents and bioactivity of Picralima nitida seed, leaf, root and stem back methanol extracts. The phytoconstituents present were identified using GC-MS (Gas Chromatography-Mass Spectrometry) analysis. The...


Hepatoprotective potential of Blepharis persica (burm. f.) o. kuntze.

Article in Press

This study aimed to assess the hepatoprotective activity of ethanol (90%) extract of Blepharis persica seeds (BPEE) in rats. The plant extract showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity as judged from the serum marker enzymes and histopathological studies on liver tissues. The acetaminophen-induced group shows a significant rise in the serum enzymes. Treatment of rats with...

Author(s):Vichitra Kaushik, Gagandeep Chaudhary, Shoaib Ahmad, Vipin Saini, A. Pandurangan, Manish Kumar and G. Arunachalam

Characterization of the chemical composition of Lippia alba Mill. essential oil in the dry and rainy seasons

Article in Press

Lippia alba is a native species popularly known as "lemon balm", used in folk medicine for the treatment of several diseases. This work aims to study the ethnobotany of L. alba and to determine the chemical composition of essential oils from the fresh leaves of L. alba during both rainy and dry seasons. The volatile contents of the oil samples were determined by Gas Chromatography coupled to Mass Spectrometry - GC/MS. The...

Author(s):Rodrigo Dias Alves, Ianara Mendonça da Costa, Francisca Overlânia Vieira lima, Luciana Cristina Borges Fernandes, Dinalva Brito de Queiroz, Eduardo Pereira de Azevedoc, Jacqueline do Carmo Barreto and Fausto Pierdoná Guzen

Medicinal Value of the Seed Essential Oil of Eucalyptus citriodora Hook

Article in Press

Eucalyptus essential oil is an important aroma-therapeutic agent in the treatment of diverse diseases and ailments in human and animals. The aim of this study was to determine the composition and pharmacological properties of the seed essential oil of E. citriodora from Nigeria. The essential oil was extracted by hydro-distillation using Clevenger-type apparatus and analyzed using GC-MS. The total phenolic content,...

Author(s):Ololade, Z.S. and Olawore, N.O.

Acute and subchronic toxicity assessment of Melastomastrum capitatum Fern. leaf methanol extract in Wistar albino rats

Article in Press

This study was carried in order to determine short-term (acute) and long-term(subchronic) effects of Melastomastrum capitatum leaf methanol extract in the management and treatment of certain diseases in traditional and complementary medicines by many villages in Mambila Nigeria. Acute and subchronic toxicities were carried out in accordance with the Organization for Economic Cooperation and Development (OECD) guidelines....

Author(s):Cletus Anes Ukwubile, Abubakar Ahmed, Umar Adamu Katsayal, Jamilu Ya'u and Henry I. Nettey


Article in Press

The roots of Chasmanthera dependens were studied to determine their active constituents and antimicrobial activity. A phytochemical investigation of C. dependens using chloroform and methanol extracts led to the isolation and identification of the following secondary metabolites; alkaloids, flavonoids, tannins, phenolics, carbohydrates, reducing sugars, terpenoids, steroids, saponins. The antimicrobial activities of these...

Author(s):Anosike, Chioma Assumpta., Nwachukwu, Justus Nmaduka, Ogbozor, Chinedu. Samuel and Madueke, Chidi Augustine.


Article in Press

Objective: To study detailed Pharmacognostic profile and preliminary phytochemical investigation of the leaves of Indigofera tinctoria Linn. commonly known as ‘indigo’ belongs to the family Fabaceae. It is distributed through the hotter parts of India. Medicinal uses include the juice of the leaves as a prophylactic against hydrophobia, and as a decoction for blennorrhagia; plant extract as the treatment for epilepsy,...

Author(s):Dhanapal Venkatachalam


Article in Press

Objectives: This study covers the microscopic studies, the phytochemical screening, acute toxicity evaluation and anti-inflammatory activity of the methanol extract of the leaves of Sabiceabrevipes. This plant has not been studied extensively; even when such studies were done; the focus was on the root rather than the leaf, which is easier to harvest and more abundant. Method: Free hand sections were used for anatomical...

Author(s):Michel Kenne Tchimene, Sunday Patrick Gaza Anze, Christopher Obodike Ezugwu and Maurice Mmaduakolam Iwu

Comparative Proximate Composition and Hypoglycemic Properties of Three Medicinal Plants (Verononiaamygdalina, AzadirachtaindicaandMoringaoleifera).

Article in Press

The present study sought to investigate proximate composition in relation to the short and long term hypoglycemic effects of ethanol/water extracts of Verononiaamygdalina, AzadirachtaindicaandMoringaoleifera on hyperglycemic rats. Hyperglycemia was induced by single intra-peritoneal injection of 0.1 mol/L alloxan monohydrate in citrate buffer (pH = 4.5); dosage = 140 mg/kg; b/w.Hyperglycemic rats received separate dose of...

Author(s):Chikezie P.C and Ojiko O.A

Anti-inflammatory and antioxidant activity of Ixora coccinea stems

Article in Press

Background and objective: Ixora coccinea has mentioned in Ayurveda as Paranti and traditionally stems used in inflammatory diseases like sprains, eczema, contusions and boils. Present study deals with assessment of anti-inflammatory and antioxidant activity of extracts of I. coccinea stem. Methodology: Anti-inflammatory activity was accessed by in vivo carrageenan-induced paw edema in rat and in vitro human red blood...

Author(s):Ajaykumar Rikhabchand Surana and Rajendra Dayaram Wagh


Article in Press

Tea and coffee have been consumed for hundreds of years for their flavour and stimulating properties. Nowadays, caffeine is receiving an increasing interest in food and pharmaceutical industries due to its central nervous system CNS stimulating properties, peripheral vasoconstriction, relaxation of the smooth muscle and myocardial stimulation. Caffeine constitutes an average of 4% of tea leaf and 1.5% of coffee bean. The...

Author(s):Hattem Mohamed Mekky


Article in Press

Diabetes mellitus is a metabolic disorder in the endocrine system. This dreadful disease is found in all parts of the world and is becoming a serious threat to mankind health. There are lots of chemical agents available to control and to treat diabetic patients, but total recovery from diabetes has not been reported up to this date. Alternative to these synthetic agents, plants provide a potential source of hypoglycemic...

Author(s):Maninder Kaur

Fungal metagenomes in polyherbal medicines used for the treatment of tuberculosis

Article in Press

The traditional systems of medicine have significantly become more accepted in the developed and developing countries due to their curative property, less toxicity and minimal side effects. However, several studies have shown that they are associated with microbial contaminants. This study aimed at identifying fungi in nine polyherbal medicines used for the treatment of tuberculosis in Eastern Cape Province, South Africa....

Author(s):Elizabeth Bosede Famewo, Anna Maria Clarke and Anthony Jide Afolayan

Antimicrobial activity of leaf and flower extracts of Ocimum gratissimum on selected microorganisms

Article in Press

The antimicrobial activities of flower and leaf extract of Ocimum gratissimum obtained from the garden of the Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology Ghana, was tested against Staphylococcus aureus, Bacillus subtilis (Gram positive bacteria), Klebsiella pneumonia, Pseudomonas aeruginosa, Escherichia coli (Gram negative bacteria) and Candida albicans (fungi). These...

Author(s):Aryee Feizel Ayitey

Development of Validated High performance thin layer chromatography method for simultaneous determination of quercetin and kaempferol in Thespesia populnea

Article in Press

Thespesia populnea L. (Family: Malvaceae) is a well-known medicinal plant distributed in tropical regions of world and cultivated in south Gujarat and indicated to be useful in cutaneous affections, psoriasis, ringworm and eczema. Bark and fruits are indicated in the diseases of skin, urethritis and gonorrhea. The juice of fruits is employed in treating certain hepatic diseases. The plant is reported to contain flavanoids,...

Author(s):Hiteksha Panchal, Aeshna Amin and Mamta Shah

Potential of Kelakai plants (Stenochlaena palustris (Burm.F.) Bedd.) from Central Kalimantan as aphrodisiac

Article in Press

The necessity for traditional medicine is efficacious as aphrodisiac increases every year. Dayak community believes that Kelakai roots have efficacy as an aphrodisiac drug, but no studies were conducted relating to the efficacy of the Kelakai roots.Traditional medicinal products are efficacious as aphrodisiac have a hormone-like effect, usually contain active ingredients that have estrogenic properties among other things...

Author(s):Fahruni, Rezqi Handayani and Susi Novaryatiin


Article in Press

Garcinia hanburyi belongs to the family Clusiaceae. The whole plant was dried, extracted to obtain Xanthone rich extract. Phytochemical studies of extract showed the presence of Phenols, Alkaloids, steroids, resins and saponins. The natural sources such as a plants are an abundant source having various medicinal properties. In the present study, Garcinia hanburyi has been selected to test for the Anti-inflammatory activity...

Author(s):J. Narayanan and V.CHITRA

Biochemical and antibacterial activity of Jojoba Oil ‘Simmondsia chinensis’ in rats

Article in Press

This study has evaluated the antibacterial effect of Jojoba oil (J.O) in vivo against Staphylococcus aureus. One hundred mature male Sprague Dawley rats were divided into four groups, including the control groups and the groups treated with J.O. as part of the diet mixture (2.5% of total body weight). Our findings suggest a significant increase in body weight gain (94.0 ±5.404 g for J.O treated rats in comparison to 72.0...

Author(s):Shahd Abuhelal

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