Abstract

Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are the most frequently prescribed therapeutic agents, used for the treatment of rheumatic diseases, because they have analgesic, antipyretic and anti- inflammatory actions. Diclofenac (Voltaren) is a well-known member of the acetic acid family of NSAIDs, used to reduce inflammation and pain associated with arthritis osteoarthritis, and ankylosing spondylitis. There is considerable interest in the toxicity of diclofenac because of its clinical use and for the study of the mechanisms of nephrotoxicity, renal dysfunction, hematotoxicity and hypersensitivity reactions. In the present study we have reported the basic metabolites and activities of enzymes were studied in different tissues against adjuvant and diclofenac sodium treatment. The change due to the adjuvant treatment was attributed to the inflammation associated changes and the further alteration in diclofenac sodium was implicated to its toxic manifestation, besides the drug side effect is caused by metabolic idiosyncrasy.

Key words: Inflammation, adjuvant arthritis, metabolites, enzymes.