In-vivo anti-inflammatory activity of different parts of Adansonia Digitata
June 2021
The aim of the study is to investigate the anti-inflammatory property of the different parts of Adansonia digitata (Malvaceae) extracts. A. digitata is an important medicinal plant to West Africa including Ghana. The plant is used effectively in folk medicine to treat inflammatory diseases such as joint disorders, asthma, toothache and painful swelling. Carrageenan-induced pedal oedema in 7-day old chicks was was the...
Indigenous knowledge of plant uses by the community of Batiaghata, Khulna, Bangladesh
June 2021
Southwestern region of Bangladesh is very rich in floral diversity, and their diversified uses. An extensive survey was conducted to investigate ethnobotanical applications of botanical species by the community of Khulna, Bangladesh. We focused on plants and community relationships, identify the most important species used, determine the relative importance of the species surveyed and calculated the Fidelity level (FI)...
Polyphenols quantification and antioxidant activity of methanolic and aqueous extracts from eight medicinal plants used to manage avian diseases in Burkina Faso
May 2021
The present study aimed to quantify the polyphenols and evaluate the antioxidant activity of methanolic and aqueous extracts from eight medicinal plants used by the poultry farmers to manage avian diseases in Burkina Faso. Total phenolics and total flavonoids were quantified using Folin-Ciocalteu and AlCl3 reagents, respectively. The antioxidant activity was evaluated using three methods:...
In vivo study of antiplasmodium and histological activity of Garcinia kola and Aloe vera extracts against falciparum malaria
May 2021
This study focuses on testing the efficacy of herbal remedy used in many homes within the South-Eastern part of Nigeria to treat malaria and also the histopathological effect of the remedy on albino rats. Twenty rats were procured and distributed with five rats to one group. Group 1 received Garcinia kola and Aloe vera extracts, Group 2 received only G. kola extract, Group 3 is negative control and Group 4 is positive...
Bioactive profile of mandacaru fruits and cytotoxicity against the L929 cell line
May 2021
Mandacaru (Cereus jamacaru DC. Subsp. Jamacaru) is native to the Brazilian Caatinga and is part of the Cactaceae family. Mandacaru fruits are attractive in taste and flavour, although they are not widely commercialised. However, there is limited scientific literature on the composition of this fruit. Therefore, the present work was aimed at analysing the physicochemical composition, as well as in vitro antioxidant...
Berberis vulgaris aqueous extract prevention of carbon tetrachloride induced hepatotoxicity and lipopolysaccharides/paracetamol induced hepatitis in rats
May 2021
The aim of this study was to evaluate the effect of Berberis vulgaris water extract (BWE) against CCl4-induced hepatotoxicity and LPS/PCM induced- hepatic inflammation in the experimental animal models. CCl4 (100 ug/kg, oral) administration for 28 days as well as the co-administration of LPS (250 ug/kg bw) and PCM (2 g/kg bw) for 28 days resulted in massive elevation in serum and hepatic prooxidants and inflammatory...
New naphthalene derivative isolated from Diaporthe sp. host to Syzygium cordatum Hochst.ex Krauss plant
May 2021
Fungal endophytes are regarded as inexhaustible sources of pharmaceuticals and agrochemicals with profound antibacterial, anticancer or antifungal activities. Diaporthe sp., an endophytic fungus residing in medicinal plant S. cordatum, showed a good antagonism against bacterial pathogens of beans; Pseudomonas syringae pv phaseolicola (Psp) and Xanthomonas axonopodis pv phaseoli (Xap), with zones of inhibitions of 14.00...
Antiurolithiatic activity of selected plants extracts against calcium oxalate crystals
April 2021
The present study was designed to evaluate the antiurolithiatic activity of selected plants extracts (Achyranthes aspera, Lawsonia inermis, Ficus benghalensis, Raphnus sativus and Macrotyloma uniflorum). The methanol extract of selected plants was analysed for in-vitro antiurolithiatic activity using nucleation, aggregation and growth assay of calcium oxalate (CaOX) monohydrate crystals. The nucleation, aggregation and...
Anti-hyperglycemic effects of Stemonocoleus micranthus (Fabaceae) stem bark on alloxan-induced hyperglycemic rats
April 2021
This study evaluated the anti-hyperglycemic potential of Stemonocoleus micranthus Harms. (Fabaceae) stem bark. Three models used in this study were: normoglycemic animal model, oral glucose tolerance test (OGTT) and alloxan-induced hyperglycemic model for acute and prolonged administration. Five (5) groups of rats (n=5) were used for all models; group 1 served as the control (received 2 ml/kg of distilled water; p.o.),...
Antibacterial effects of the organic crude extracts of freshwater algae of Sulaymaniyah, Kurdistan Region, Iraq
April 2021
In the recent past, the importance of freshwater algae has grown enormously due to their antibiotic activity against certain species of bacteria known for several disease states like endocarditis, external otitis, skin rash, etc. Also, there is a growing concern among the immunocompromised individuals that they may be susceptible to antibiotics and anti-fungal resistant infections resulting in increased fatality rates....
Antioxidant effect of Hymenaea courbaril L (Jatobá) sap on the healing of wounds on mice
April 2021
The use of natural products with curative action is a common cultural practice in the Brazilian Amazon, but little explored scientifically. The effect of Hymenaea courbaril L sap extract and its contribution to wound healing in mice was evaluated. The antioxidant potential of the extract was studied using the radical 1,1-diphenyl-2-picrilhidrazil and 2,2'-azino-bis (3-ethyl benzothiazoline-6-sulfonic) acid radical,...
Seasonal impacts on antifungal activity and chemical composition of extracts from medicinal plants Turraea holstii and Clausena anisata
April 2021
Curative dependence on season of harvest for medicinal plants is an alleged claim by traditional health practitioners. This study aimed to verify these claims by investigating antifungal activity and chemical profiles of two traditionally used medicinal plant species: Turraea holstii and Clausena anisata harvested in the rainy and dry seasons, with a view of establishing appropriate the season for optimal activity. The...
Farmers’ awareness and ethno-veterinary practices regarding porcine cysticercosis in the province of Boulkiemde, Burkina Faso
April 2021
Porcine cysticercosis is a major public health issue in Burkina Faso. This study investigated farmers’ awareness and ethno-veterinary practices regarding this disease in Boulkiemde province, Burkina Faso. A survey was done with 132 randomly selected pig farmers in 10 villages of two municipalities of Boulkiemde province, using a semi-structured questionnaire. The majority of interviewed farmers (54%) were from the...
Chemical and organic fertilizer: The effect on apiin production by Petroselinum crispum var. neapolitanum Danert
March 2021
Parsley (Petroselinum crispum var. neapolitanum Danert) is a vegetable species with potential for pharmaceutical use because it contains apiin, a flavonoid that stands out for having biological activities, such as antioxidant. The aim of this study is to evaluate the influence of chemical or organic fertilizers on the nitrogen metabolism and production of flavonoids in parsley at different stages of development, aiming...
Chambá (Justicia pectoralis) syrup for the treatment of cough and respiratory symptoms: A randomized clinical trial
March 2021
Cough is a common pediatric complaint, resulting in frequent doctor’s office or hospital visits. In Brazil, the leaves of chambá (Justicia pectoralis) have been used extensively in herbal preparations for the treatment of many respiratory problems such as cough, bronchitis, and asthma. Thus, this study aimed to assess the effectiveness of chambá syrup for the treatment of cough and respiratory...
Toxicological evaluation of Zanthoxylum zanthoxyloides (Lam) Zepernick & Timler root bark used as biopesticide and medicine
February 2021
Toxicological studies were carried out to investigate the effect of consumption of Zanthoxylum zanthoxyloides root bark widely used in traditional medical practices and as protectant of stored cereal products in Nigeria, using albino rats. Serum, kidney and liver were tested for oxidation stress and tissue damage markers; aspartate amino transferase (AST), alanine amino transferase (ALT), urea, bilirubin and creatinine...
Plants for veterinary use in the Montaña Palentina region (Palencia, Spain)
February 2021
Profound social changes that have occurred in recent decades in rural society have led to the abandonment of ethno veterinary practices and knowledge, traditionally used to treat and prevent animal diseases. The main objective of this ethno botanical work is to document the traditional veterinary uses of plants in the Montaña Palentina region (Palencia, Spain). The data obtained has been compiled through 139...
Aphrodisiac activity of ethanol extract and fractions of Fadogia cienkowskii Shweinf. Rubiaceae roots in albino rats
February 2021
Fadogia cienkowskii is a shrub whose roots are used in many communities of Northern Nigeria to improve sexual performance; however, there is no scientific study to verify this claim. This study determined the effect of 70% ethanol extract of F. cienkowskii roots and its fractions (ethyl acetate, n-butanol, and residual ethanol) on mating behaviour (mounting, intromission and ejaculation) and serum testosterone...
Qualitative and quantitative phytochemical profiling of crude fractions of Pechuel-Loeschea leubnitziae leaves
February 2021
Pechuel-Loeschea leubnitziae is a predominant medicinal plant in Namibia. It is traditionally utilized in treatment of gastrointestinal issues, sexually transmitted infections and common cold. Despite its therapeutic potential, the phytochemicals profile and compounds compositions are yet to be scientifically validated. This study was conducted to determine the spectrum and total phytochemical constituents present in P....
Occurrence of calcium oxalate crystals in some wild plants used in traditional medicine in Saudi Arabia
February 2021
Plants are widely used in traditional medicine, but could be detrimental to patients, due to the presence of some harmful substances such as calcium oxalate (CaOx) C2CaO4 crystals. The presence, morphology and distribution of CaOx crystals were investigated in 60 wild, herbal plant species from the Al Qussim Region, Saudi Arabia. This was done via light microscopy of transverse sections of stems and leaves using light...
Ethnomedical survey of plants used for the management of HIV and AIDS-related conditions in Mbulu District, Tanzania
January 2021
The aim of this Study was to document medicinal plants used in the management of HIV and AIDS-related conditions in Mbulu District. An ethnomedical survey was conducted using a semi-structured questionnaire. The main HIV and AIDS-related conditions considered during this study were; cough, frequent fevers, diarrhea, weight loss, oral thrush, genital warts, candidiasis, abscesses, skin rashes, shingles and venereal...
Chemical composition and antibacterial activity against Escherichia coli of extracts of a common household plant
January 2021
Plants have long been a source for a wide variety of compounds with medicinal properties; of significant interest are plant antimicrobial compounds. Given the continual increase in bacterial resistance, it is imperative that new antimicrobial compounds need to be discovered. The purpose of this study was to screen some common household plants for antibacterial activity, specifically against Escherichia coli. Leaves of...
Development and validation of a new method to quantify vitexin-2''-O-rhamnoside on Passiflora L. extracts
January 2021
The genus Passiflora L. is the most representative of the Passifloraceae family and includes about 500 species. The aim of this work was to analyze three different passion fruit species in relation to vitexin-2´´-O-rhamnoside content by high-performance liquid chromatography coupled to a diode-array ultaviolet detector. Samples were prepared by water infusion (10% w/v), dried by lyophilization, and stored in...
Ethnobotanical study of selected medicinal plants used for the treatment of respiratory diseases in Southern Brazil
January 2021
This survey explored the ethnobotanical uses of selected medicinal plants; Adiantum raddianum C. Presl. (Pteridaceae), Lippia alba (Mill.) N. E. Brown (Verbenaceae) and Coronopus didymus (L.) Sm. (Brassicaceae) used for respiratory diseases in Southern Santa Catarina (Brazil). This is timely as the incidence of respiratory disease is increasing in this state. Information was obtained through both interviews using a...
The study on antioxidant activity of ulvan-calcium derivative
January 2021
Ulvan is a water-soluble polysaccharide that is extracted from the algae Ulva pertusa (Chlorophyta). In this study, ulvan-calcium derivative (U-calcium) was prepared and calcium content was 5.2%. Ulvan-calcium could effectively scavenge on 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis (3-ethyl-benzothiazolie-6-sulfonic acid) (ABTS), hydroxyl, and superoxide radicals. The inhibition rate on superoxide...
Myrothamnus flabellifolius attenuates streptozotocin-high energy diet-induced type 2 diabetes in male sprague dawley rats
December 2020
Several medicinal plants have anti-diabetic properties and can be considered as an alternative therapy because of their actions which are like those of conventional antidiabetic drugs. In this study, we investigated Myrothamnus flabellifolius (MF) ethanol: water (70:30) extract for its possible anti-diabetic potential in streptozotocin-high energy diet (STZ-HED) induced type 2 diabetes mellitus (T2DM) rats and its...
Inhibitory effects of Anadenanthera colubrina (Vell.) Brenan stem bark extract on α-glucosidase activity and oxidative stress
November 2020
In this study, we investigated the promising potential of Anadenanthera colubrina bark extract (BEAc) as a product to combat diabetes mellitus (DM). We evaluated the inhibitory effects of BEAc on α-glucosidase and the oxidation of biomolecules, as well as its main phytoconstituents. In terms of free radical scavenging, BEAc exhibited a dose-effect relationship. BEAc was more efficient than rutin and butylated...
Lavandula angustifolia aqueous extract ameliorates anxiety and depressive-like behaviors in chronic mild stress-treated male rats
November 2020
The study aims to show the possible anxiolytic and antidepressant-like properties of an oral lavender’s flower aqueous extract (LAE) in chronic mild stress (CMS) model of rats. Test and control rats received LAE (200 or 400 mg/ kg) and distilled water respectively. Tests of Sucrose preference (SP), elevated plus maze (EPM), and open field (OFT) were used to evaluate rats’ behavioral changes. The...
In vitro antioxidant and cytotoxic activity of the root extract of Aspilia mossambicensis (Oliv) Wild (Asteraceae)
November 2020
Aspiliamossambicensis(Oliv) Wild is used by Traditional Health Practitioners in northeastern Tanzania, for treatment of cancers. In order to evaluate these claims root powder of the plant was extracted with dichloromethane: methanol (1:1), followed by vacuum liquid chromatography fractionation to obtain dichloromethane, ethyl acetate and methanol fractions which were screened for brine shrimp toxicity and antioxidant...
Evaluating the antibacterial, antioxidant and wound healing properties of the stem bark extract of Khaya grandifoliola (Welw) CDC (Meliaceae) (African mahogany)
November 2020
The study was conducted to evaluate the antibacterial, antioxidant, and wound healing properties of the stem bark of Khaya grandifoliola (Welw) CDC (Meliaceae). A preliminary phytochemical screening conducted showed the presence of tannins, alkaloids, saponins, reducing sugars, flavonoids, terpenoids, and phenols in the stem bark (KG) as well as its ethanol extract (KGE). The antibacterial activity of KGE was evaluated...
Phytochemical screening and antimicrobial activity of methanol extract of Garcinia Kola Heckle fruit mesocarp
November 2020
The phytochemical screening and antimicrobial activities of the methanol extract of Garcinia kola fruit mesocarp were investigated against four bacteria and two fungi in the study. The extract was investigated for the presence of phytochemicals using standard phytochemical screening methods. The results revealed the presence of flavonoids, tannins, alkaloids, terpenoids, cardiac glycosides, and reducing sugar. The...
Future molecular medicine from white frangipani (Plumeria alba L.): A review
October 2020
White frangipani (Plumeria alba L.) is tropical and subtropical plants, have been familiar used in many traditional medication as well as aromatherapy, especially for the flower part. Scientific study, but was not so many, reporting some pharmacological and toxicological effects of this plant which lead to more depth study at molecular level. This review describes the pharmacological and toxicological effect of the...
Evaluation of antioxidant and protective effect against genotoxic damage of two extracts of chaya leaves (Cnidoscolus aconitifolius)
October 2020
Stress, excessive consumption of processed foods, pollutants and many other factors of today's life have caused oxidative stress in our body and damage to genetic material in our cells, leading to diseases such as diabetes, hypertension, cancer, metabolic syndrome, among others. Medicine has returned to take up traditional remedies mainly in plants. Chaya (Cnidoscolus aconitifolius) has been studied in this regard,...
Antibacterial activities of ethyl acetate and methanol leaf extracts of Psidium guajava and Carica papaya on bacterial pathogens isolated from manual toothbrushes
October 2020
Toothbrush has become a potential source of infection, owing to contamination by various pathogens as a result of poor oral hygiene awareness and practices. This study investigated the antibacterial activities of ethyl acetate and methanol leaf-extracts of Psidium guajava (guava) and Carica papaya (paw-paw) on bacteria pathogens isolated from toothbrushes. A total of 100 manual used toothbrushes of different brands were...
Larvicide and repellent activity of Hypenia irregularis (Benth.) Harley in the alternative control of mosquito Aedes aegypti
October 2020
Dengue is an emerging epidemic disease and among those transmitted by the Aedes aegypti mosquito, it is the one with the highest number of cases and cases with death. With the wide dissemination of the beneficial effects of medicinal plants and the use in agriculture as a pesticide, studies on the prospection of plants with toxic activity have been increasing, highlighting extracts and essential oils. The objective of...
Eerdun Wurile protects neuron and promotes neurite outgrowth through regulation of apoptotic gene expression in PC-12 cells
October 2020
Eerdun Wurile (EW) is one of the most widely used traditional Mongolian medicines for stroke recovery. Previous studies revealed that EW regulates brain gene expression in a rat model of middle cerebral artery occlusion (MCAO). However, the fraction of active components and the specific genes regulated by such fractions have not been elucidated clearly. The study shows that the extracts of EW regulate the expression of...
Anticonvulsant activities of friedelan-3-one and n-dotriacontane both isolated from Harungana madagascariensis Lam (Hypericaceae) seeds extracts
October 2020
Chemical investigation of the crude methanol/methylene chloride (1:1) extract of the seeds of Harungana madagascariensis resulted in the isolation of two known compounds namely n-dotriacontane and friedelan-3-one. The structures of the isolated compounds were determined on the basis of 1D NMR spectroscopy and comparison with literature data. The crude extract and the two compounds were evaluated for their anticonvulsant...
Optimization by mixture design of the antimicrobial activities of five selected essential oils
October 2020
The individual antimicrobial activities of essential oils have been reported by many authors. However, there is little information about the effects of their mixtures in order to maximize their effect and reduce the growing resistance of pathogens to existing medicines. So, the aim of this work is to optimize the antibacterial and antifungal activities of essential oils from Plectranthus glandulosus, Ocimum gratissimum,...
Hypoglycaemic effects of Salvia officinalis extracts on alloxan-induced diabetic Swiss albino mice
October 2020
Diabetes mellitus is the fourth killer disease globally. The available management strategies are quite expensive and sometimes unsafe. This necessitates the need for bio-active drugs from medicinal plants. Although Salvia officinalis (sage) is used in herbal medicine, the scientific validation for anti-diabetic effects of various extracts has been elusive. The present study aimed to determine and compare the...
Chemo preventive effect of methanol extract of Anacardium occidentale nut shell on ultra-violet radiation induced skin damage
September 2020
Anacardium occidentale nut shell liquid has been used for decades especially by natives of South America, Asia and Africa in the treatment of topical skin diseases, abrasion and cancerous ulcers amongst others. Chronic exposure to sunlight can lead to skin damages including erythema, edema, hyperplasia, formation of sunburn cells, photo-aging, suppression of the immune system and skin cancer. This study was aimed at...
Ethnobotanical study of plants used against onchocerciasis in the far north region of Cameroon
September 2020
Despite the multitude of studies which have shown the use of medicinal plants in the management of parasitic diseases, little data was available on the plants used against onchocerciasis. Ethnobotanical surveys were carried out among traditional healers in the Far North region of Cameroon. Studies were conducted from July 2017 to May 2018 through direct interviews using a semi-structured questionnaire taking into...
In vitro antibacterial activity of Psidium guajava (Guava) leaves extract on carbapenem-resistant Klebsiella pneumoniae causing multi-drug resistant systemic infections
September 2020
Systemic bacterial infections affect almost all part of the human body systems leading to infections such as urinary tract infections, septicemia, meningitis, pneumonia, peritonitis and gastritis. Carbapenems have been used as drug of choice in the treatment of systemic infections. Studies have indicated that Enterobacteriaceae are producing enzymes such as carbapenemases, which inactivate carbapenems. There ...
Protective effect of piperine from Piper chaba fruits on LPS-induced inflammation in human intestinal cell line
September 2020
Piper chaba is a flowering vine in the family of piperaceae. It is a spicy plant widely used as food and herbal medicine in the South and Southeast Asian countries. The study evaluated anti-inflammatory and immunomodulatory activities of a major alkaloid extract, piperine, from P. chaba fruits on human colonic epithelial cells. The effects of piperine extract on cell viability, pro-inflammatory cytokine inhibition, and...
Antibacterial, total phenols, antioxidant, and fatty acids of the lyophilized body fat of Podocnemis expansa (Schweigger, 1812) from farm in Acre State, Brazil
September 2020
Podocnemis expansa (Podocnemididae) is a chelonian of suborder Pleurodira and is popularly known as Amazon turtle. The animal’s body fat was removed from the farm in Xapuri city in Acre State, Brazil. The fat was lyophilized and the oil was extracted by the Soxhlet method using hexane, as a solvent. The fatty acids majority, identified and quantified by gas chromatography-flame ionization detector, were:...
Screening open source traditional Chinese medicine extracts for growth-inhibiting properties towards Acinetobacter baumannii
September 2020
Infections caused by Acinetobacter baumannii and other pathogenic bacteria are a worldwide concern due to their increasingly prevalent multidrug resistance. World leaders and health organizations across the globe have voiced their concerns over antibiotic resistance and the critical need for the development of novel antibiotics. Although the number of new antibiotic drugs entering the marketplace in recent years has...
Medicinal plants used against malaria by traditional therapists in malaria endemic areas of the Ségou region, Mali
September 2020
West Africa is one of the regions in Africa with the highest levels of malaria transmission a descriptive study was carried out to inventorise the medicinal plants traditionally used against malaria by traditional therapists in five malaria endemic areas of the Ségou region, in Mali. Sixty-five traditional therapists were randomly selected to be part of the study. Questions were posed using semi-structured...
Larvicidal activity of Juniperus procera extract against anopheles mosquito in in vitro, North Western Ethiopia
September 2020
Mosquitoes are the major health threat as they transmit plasmodium parasites that cause malaria. Since mosquitoes developed resistances towards insecticides, investigators are searching for alternative control measures. Bioactive plant chemicals have been identified to serve as a defense mechanism against insects’ larvae. Therefore, the aim of the study was to evaluate larvicidal activities of Juniperus procera...
Ethnobotanical survey of medicinal plants commonly used in snakebites in North Western Nigeria
September 2020
The incidence of snake bite in rural West Africa is reportedly high with an 11–17% mortality rate. Nigeria has one third of the cases for snake bite cases in this region.Thus, most tribes in North-western part of Nigeria depend on medicinal plants for snakebites. However, it appears that a gap exists on documentation of these plants especially tropical flora used in the management of snake bite. This led to...
Phytochemical screening and antibacterial activity of dried pods of Prosopis Africana
August 2020
Evolving resistant microbial strains have posed a great challenge on antibacterial chemotherapy in recent times. Search for novel antimicrobial agents has therefore remained a highly prospective area of research, especially those of plant origin. To this end, Prosopis africana pod used in West Africa in traditional medicine was evaluated for phytochemical constituents using standard procedures. Antibacterial activity...
Determination of total phenolic compounds, antioxidant activity and nutrients in Brazil nuts (Bertholletia excelsa H. B. K.)
August 2020
Bertholletia excelsa is native to the Amazon, and it grows in the forests that border the great rivers of the Amazon. This tree brings interest in the commercialization of its fruit, which is called the urchin and almond. Bertholletia excelsa has antioxidant properties, and it is rich in phenolic compounds. In this research, the antioxidant capacity of the Brazilian nut from the city of São João da Baliza...
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