African Journal of
Agricultural Research

  • Abbreviation: Afr. J. Agric. Res.
  • Language: English
  • ISSN: 1991-637X
  • DOI: 10.5897/AJAR
  • Start Year: 2006
  • Published Articles: 6688

Full Length Research Paper

Analysis of the codon use frequency of peroxisome proliferator-activated receptors (PPAR) family genes from different species

Wenzong Lu*, Guangfeng Jia, Xiangyan Meng, Chen Zhao, Liang Zhang, Haixian Pan, Yumiao Ren and Yuan Ni
Department of Biomedical Engineering, Xi’an Technological University, Xi’an, Shaanxi Province, 710032, People’s Republic of China.  
Email: [email protected]

  •  Accepted: 09 April 2012
  •  Published: 05 June 2012


In mammals, peroxisome proliferator-activated receptors (PPAR) play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. In this paper, the relative synonymous codon use frequency of 32 PPAR family genes from seven mammal species (Homo sapiensMus musculusRattus norvegicusBos taurusMacaca mulatta,Oryctolagus cuniculusSus scrofa) were analyzed by correspondence analysis and hierarchical cluster method. The results indicated that the gene function is the dominant factor that determines codon usage bias in PPAR family genes, while species is a minor factor that determines further difference in codon usage bias for genes with similar functions.


Key words: Peroxisome proliferator-activated receptors, synonymous codon use, correspondence analysis, codon usage bias.