African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Full Length Research Paper

Tea Artemisia annua inhibits Plasmodium falciparum isolates collected in Pikine, Senegal

Gueye Papa El hadji Omar1, Diallo Mouhamadou1*, Deme Awa Bineta1, Badiane Aida Sadikh1,2, Dior Diop Mare1, Ahouidi Ambroise1, Abdoul Aziz Ndiaye2, Dieng Thérése2, Lutgen Pierre3, Mboup Souleymane1 and Sarr Ousmane1
  1Molecular Biology Unit, Bacteriology-Virology Laboratory at Aristide Le Dantec Hospital, 30 Pasteur Avenue, BP 7325 Dakar, Senegal. 2Department of Parasitology and Mycology, University Cheikh Anta Diop, Dakar, Senegal. 3Iwerliewen Fir Bedreete Volleker, Luxemburg NGO, Luxemburg.
Email: [email protected], [email protected]

  •  Accepted: 05 July 2013
  •  Published: 31 August 2013



Malaria is a major scourge of most countries in Africa which continues to defy science and technology. Several medicinal plants are traditionally used for the treatment of malaria and other protozoa infections. We aimed to assess by the Double-site Enzyme-linked Lactate dehydrogenase enzyme Immuno-detection (DELI) test for the first time in Senegal, Plasmodium falciparum isolates in vitro susceptibility to Tea Artemisia annua (TAA). In total, 40 field isolates have been tested and the mean IC50 was 0.095 µg/ml, while the IC50 for the 3D7 and W2 laboratory adapted strains were 0.14 and 0.39 µg/ml, respectively. Tea A. annua sensitivity was not obtained for three isolates because of lack of growth. The results suggest that tea A. annuahas potent antiplasmodial activity against P. falciparum strains collected in Pikine, Senegal.


Key words: Artemisia annua, enzyme-linked lactate dehydrogenase enzyme immuno-detection (DELI), Plasmodium falciparum, IC50.