African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Full Length Research Paper

Toxic effects of aqueous stem bark extract of Cassia sieberiana on some biochemical parameters in rats

W. Obidah*, U. A. Sa’ad and A. U. Wurochekke
Biochemistry Department, Federal University of Technology Yola, Adamawa State, Nigeria
Email: [email protected]

  •  Published: 31 May 2009



The aqueous extract of Cassia sieberiana stem bark was administered to groups of 4 albino rats (160 ± 10 g) at 0, 20, 60 or 180 mg/kg body weight daily by gavages for six weeks. A 7% decrease in mean body weight gain was observed in the group treated with the highest concentration of the extract (180 mg/kg). Groups treated with the extract showed significant (p < 0.05) increase in serum ALT and AST activity. Significant (p < 0.05) increase in serum urea and creatinine concentrations, together with decrease in serum total protein concentrations were observed in the group treated with 180mg/kg body weight of the extract. These results indicate that oral administration of aqueous extract of Cassia sieberianastem bark to rats result in hepatotoxicity even at lower dose levels of 20 - 60 mg/kg and nephrotoxicity at higher doses of 180 mg/kg.


Key words: Cassia sieberiana, oral, rats, repeated dose toxicity.