African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 421

Full Length Research Paper

Effects of curcumin and tetrahydrocurcumin on diabetes induced endothelial dysfunction

Natchaya Wongeakin1, Pattarin Sridulyakul2, Amporn Jariyapongskul3, Apichart Suksamrarn4 and Suthiluk Patumraj4*
  1Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. 2Faculty of Science, Srinakharintaraviroj University, Bangkok, Thailand.3Department of Physiology, Faculty of Medicine, Srinakharintaraviroj University, Bangkok, Thailand. 4Department of Chemistry, Faculty of Science, Ramkamhang University, Bangkok, Thailand.
Email: [email protected]

  •  Accepted: 17 April 2009
  •  Published: 31 May 2009



Diabetes-induced endothelial dysfunction has been well recognized for its underlining causes of oxidative stress. Therefore, several studies have worked on testing active antioxidant agents such as vitamin C and E against diabetes induced oxidative stress to preserve endothelial cells. In the present study, we assessed the effects of plant-derived antioxidant, curcumin and its analog, tetrahydrocurcumin (THC) and also its preventive qualities. Using an animal model, assessment for endothelial-dependent vasodilatation and the behavior of leukocytes were accomplished by using streptozotocin-induced diabetic rats and its mesenteric microcirculation parameters. The results indicated that both antioxidants, curcumin and THC, could significantly inhibit those abnormalities typically seen in endothelial dysfunctions (P < 0.05) in relation to their hypoglycemic and hypolipidemic properties. Unfortunately, curcumin has a poor absorption quality and as a result of this, a higher dose is needed to prevent abnormal endothelial functions. On the other hand, THC was found to be a more potent antioxidant and good therapeutic agent for diabetic patients in preventing diabetes vascular abnormalities.


Key words: Curcumin, tetrahydrocurcumin, endothelial dysfunction, diabetes.