Recent data showing that glucan stimulates defense reactions in plants through synthesis of resveratrol, led us to study the possible synergetic effects of a glucan-resveratrol complex on immune reactions in mice. We measured phagocytic activity, expression of CD4 marker on spleen cells, IL-2 secretion and antibody response. In all cases we confirmed the stimulatory effects of glucan. Resveratrol alone had either limit or has no effect. However, a combined preparation showed very strong synergetic effects. Our data support further studies of these two natural immunomodulators.
Key words: Glucan, resveratrol, phagocytosis, IL-2, immune reactions, macrophage, antibody.
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