African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Full Length Research Paper

Synergistic effects of glucan and resveratrol

Vaclav Vetvicka1* and Zuzana Vancikova2
1Department of Pathology, University of Louisville, Louisville, KY 40202, USA. 21st Medical Faculty, Department of Pediatrics, Thomayer University Hospital, Prague, Czech Republic.
Email: [email protected]

  •  Accepted: 12 April 2010
  •  Published: 30 April 2010


Recent data showing that glucan stimulates defense reactions in plants through synthesis of resveratrol, led us to study the possible synergetic effects of a glucan-resveratrol complex on immune reactions in mice. We measured phagocytic activity, expression of CD4 marker on spleen cells, IL-2 secretion and antibody response. In all cases we confirmed the stimulatory effects of glucan. Resveratrol alone had either limit or has no effect. However, a combined preparation showed very strong synergetic effects. Our data support further studies of these two natural immunomodulators.


Key words: Glucan, resveratrol, phagocytosis, IL-2, immune reactions, macrophage, antibody.