Palm kernel oil (PKO) resembles coconut oil in preparations and both are the only sources of lauric oil available on the world market. It has been shown to be used to control diseases such as cancer, obesity, and immune disorders, as an anti-aging and antioxidant agent. The present study investigated the gastric protective property of PKO against indomethacin-induced gastric ulceration in rats. 20 male Wistar rats were divided into 4 groups of 5 each. All mice in groups 2, 3 and 4, except group 1, served as controls, were fed a daily diet of 5, 10 and 25% PKO, respectively. Rats were fed a PKO-supplemented diet for 21 days prior to ulceration with a single oral dose of indomethacin (40 mg/kg body weight) on day 22. Gastric volume, gastric acid concentration, gastric pH, bicarbonate, mean ulcer index and percentage ulcer inhibition were determined. The results showed a significant decrease (P < 0.05) in gastric juice volume, gastric acid concentration and mean ulcer index in mice of groups 3 and 4 compared with mice of group 1 (control group), ants. However, a significant increase (p<0.05) was observed in gastric pH, bicarbonate, and percentage ulcer index in groups 3 and 4 rats compared to group 1 rats. These findings are indicative of the gastro-protective potentials of PKO to be capable of ameliorating indomethacin-induced gastric ulceration in rats. The probable mechanisms of action of PKO need further investigation.
Key words: Gastro-protective, NSAIDS, palm kernel oil, rats.
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