African Journal of
Medical and Health Sciences

  • Abbreviation: Afr. J. Med. Health Sci.
  • Language: English
  • ISSN: 2384-5589
  • DOI: 10.5897/AJMHS
  • Start Year: 2017
  • Published Articles: 78

Full Length Research Paper

Malaria and anemia in pregnancy: A case control study on the effectiveness of intermittent preventive treatment with Sulphadoxine Pyrimethamine against malaria and anemia in Madina

Emmanuel U. Osisiogu
  • Emmanuel U. Osisiogu
  • Department of Science Laboratory Technology, Dr. Hilla Limann Technical University, Wa, Ghana.
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Dorcas M. Afi Fumadorh
  • Dorcas M. Afi Fumadorh
  • Department of Physician Assistantship, Radford University College, Accra, Ghana.
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Genevive Afia Amoakoa Agyapong
  • Genevive Afia Amoakoa Agyapong
  • Department of Medical Statistics and Health Data Science, School of Medicine, University of Bristol, England.
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Cindy Naadei Nikoi
  • Cindy Naadei Nikoi
  • Public Health Institute, Liverpool John Moores University, England.
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Priscilla Essandoh
  • Priscilla Essandoh
  • Department of Biomedical Science, University of Health and Allied Health Sciences, Ho, Volta Region, Ghana.
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Sandra Appiah Kubi
  • Sandra Appiah Kubi
  • School of Natural Science, University of Central Lancashire, Fylde Rd., Preston PR1 2HE, UK.
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  •  Received: 23 October 2023
  •  Accepted: 13 December 2023
  •  Published: 31 January 2024


Malaria is a parasitic infection transmitted through the bites of female Anopheles mosquitoes carrying Plasmodium and is often complicated by anemia. This co-morbidity significantly contributes to maternal and fetal illnesses. Over the years, intermittent preventive treatment with Sulfadoxine-Pyrimethamine (IPTp-SP) has been a key preventive measure against malaria and anemia in pregnant women. Malaria during pregnancy is a considerable public health concern, and IPTp-SP is recommended to address this issue, although concerns about resistance exist. This study aimed to assess the effectiveness of IPTp-SP against malaria and anemia among pregnant women in Madina, Ghana. The research conducted a case-control study involving 174 pregnant women attending antenatal clinics in Madina. Blood samples were collected to assess malaria parasites and hemoglobin levels, and structured questionnaires were used to evaluate knowledge, attitudes, and perceptions. The study found that the use of IPTp-SP was associated with a significantly lower prevalence of malaria (p<0.05) and higher mean hemoglobin levels (p<0.05) compared to non-users. Most women demonstrated good knowledge and positive attitudes toward IPTp-SP. Despite its effectiveness, improving compliance is necessary to optimize the benefits of IPTp-SP against malaria and anemia during pregnancy in this region.

Key words: Anaemia, haemoglobin, malaria, parasitemia, Sulphadoxine Pyrimethamine.