African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5231

Full Length Research Paper

Changing trends in frequency and antimicrobial susceptibility of pathogens causing catheter related infections in children

Muhammad Qasim1,2*, Aizza Zafar1, Hasan Ejaz1, Hazir Rahman2, Abdul Malik Tareen3, Jafar Khan2 and Attia Bari4
1Department of Microbiology, Children’s Hospital and Institute of Child Health, Lahore, Pakistan. 2Department of Microbiology, Kohat University of Science and Technology, Kohat, Pakistan. 3Department of Microbiology, University of Baluchistan, Quetta, Pakistan. 4Department of Paediatric Medicine, Children’s Hospital and Institute of Child Health, Lahore, Pakistan
Email: [email protected]

  •  Accepted: 07 November 2012
  •  Published: 31 January 2013

Abstract

Catheter-related infections (CRIs) by bacterial pathogens are the frequent cause of nosocomial infections in hospitalized pediatric patients. The undertaken study was carried out at two different time duration in 2005 and 2011 to determine the changing trend in bacterial pathogens isolated from catheters and their antimicrobial susceptibility in children. Patients implanted with endotracheal tube (ETT), peritoneal dialysis catheter (PDC), urinary catheters (UC) and central venous catheters (CVC) were included in this study. The prevalence of the organism causing CRI and its antibiotic susceptibility was determined using standard microbiological assay. In the present study, the most frequent catheter colonizing bacteria in 2005 were Pseudomonas spp. 30% (n = 30) followed byKlebsiella spp. 27% (n = 27) and Escherichia coli 27% (n = 27). In contrast, the most frequently isolated pathogens in 2011 were found to be Klebsiella spp. 34.7% (n = 40), followed by E. coli 25.2% (n = 29) and Pseudomonas spp. 15.6 % (n = 18). Beside these commonly isolated pathogens, we have also isolated Acinetobacter spp. 9.57% (n = 11),Enterobacter spp5.21% (n = 6) and Citrobacter spp. 0.86% (n = 1) in 2011. A significant increase in the resistance of Gram negative bacteria to amikacin, co-amoxiclav, cefixime and cefpriome was documented from 2005 to 2011. On the other hand, in 2011, the resistance of Gram positive bacteria to amikacin, co-amoxiclav, fusidic acid and teicoplanin was significantly increased. The isolation of causative agents of CRIs and the antibiogram of these pathogens may be helpful for a more appropriate and optimized treatment with potential benefits for the patients as well as for the rationale antibiotic policy.

 

Key words: Catheter related infections, antimicrobial susceptibility, pediatric, nosocomial infection