African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5230

Full Length Research Paper

Efficacy of the essential oil of Origanum glandulosum Desf against skin infections With PVL-producing Staphylococcus aureus strains in mice

KHADIR Abdelmounaïm1, BENDAHOU Mourad*1, BENBELAÏD Fethi1, GHELLAÏ Lotfi1, ABDOUNE Mohamed Amine1, BELLAHSENE Chafika1, ZENATI Fatima1, ABDELOUAHID Djamel Eddine1, MUSELLI Alain2, PAOLLINI Julien2, DESJOBERT Jean-Marie2 and COSTA Jean2
1Laboratory of Applied Microbiology in Food, Biomedical and Environment (LAMAABE), Department of Biology, Faculty of Nature and Life, Earth and Universe Sciences, AboubekrBelkaïd University of Tlemcen, 13000 Tlemcen, Algeria. 2Université de Corse, Equipe Chimie des Produits Naturels, UMR-CNRS 6134, Quartier Grossetti, BP 52, 20250 Corti, France.
Email: [email protected], [email protected]

  •  Accepted: 03 May 2013
  •  Published: 21 May 2013

Abstract

Skin and soft tissue infections (SSTI) caused by staphylococcal toxins including Panton-Valentine leukocidin (PVL) have increased these last years. Treatment of these complicated infections is often difficult. The search for new methods and new antimicrobial substances is necessary. Natural products such as essential oils appear among the possible solutions. The objective of our work was to prove the effectiveness of treatment of these infections with essential oils in vivo on Wistar rats; we have chosen the oil of Origanum glandulosum from Algeria to perform this treatment because of its antiseptic properties. The treatment was done on infections induced in Wistar rats using PVL producing Staphylococcus aureus strain isolated from Tlemcen University Hospital. The results of our experiment have shown a significant decrease in the number of colonies collected from rats treated by the concentrations of 1 and 5% of O. glandulosum essential oil. The treatment of skin infections especially wounds caused by PVL positive S. aureus is possible with the essential oil of O. glandulosumwhich seems to be effective in eradicating the germ from infected wounds.

 

Key words: PVL-producing, Staphylococcus aureus, essential oil, skin infection,Origanum glandulosum.