African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

The contribution of host cells to dengue virus infectivity

Woraphol Rattanachuen, Lukkana Suksanpaisan, Nitwara Wikan and Duncan R. Smith*
Molecular Pathology Laboratory, Institute of Molecular Biosciences, Mahidol University, Thailand.
Email: [email protected]

  •  Published: 18 January 2011



Dengue virus infections remain a significant worldwide public health problem, causing millions of new infections each year. Transmitted by mosquitoes of the Aedes genus, the virus is capable of replicating in a number of different cells of both mosquito and human origin, but the molecular mechanism of infection remains largely unknown. This study sought to determine if the host cell in which a virus was produced had an effect on its subsequent ability to infect other cells. The study used dengue serotype 1 and 2, propagated in both insect (C6/36) and mammalian (Hep3B liver cells) to infect both C6/36 and Hep3B cells. Results showed clearly that both serotype and host cell modulated the ability of the virus to infect cells.


Key word: Aedes, dengue, flavivirus, infection, liver.