African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5181

Full Length Research Paper

Performance of the PanbioTM COVID-19 Ag Rapid Test in a health care setting in Ouagadougou, Burkina Faso

Ouedraogo Henri Gautier
  • Ouedraogo Henri Gautier
  • Institut de Recherche en Sciences de la Santé (IRSS) / Centre National de la Recherche Scientifique et Technologique (CNRST), Ouagadougou, Burkina Faso.
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Zoure Abdou Azaque
  • Zoure Abdou Azaque
  • Institut de Recherche en Sciences de la Santé (IRSS) / Centre National de la Recherche Scientifique et Technologique (CNRST), Ouagadougou, Burkina Faso.
  • Google Scholar
Sagna Tani
  • Sagna Tani
  • Institut de Recherche en Sciences de la Santé (IRSS) / Centre National de la Recherche Scientifique et Technologique (CNRST), Ouagadougou, Burkina Faso.
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Soubeiga Serge Théophile
  • Soubeiga Serge Théophile
  • Institut de Recherche en Sciences de la Santé (IRSS) / Centre National de la Recherche Scientifique et Technologique (CNRST), Ouagadougou, Burkina Faso.
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Compaoré Tegwinde R
  • Compaoré Tegwinde R
  • Institut de Recherche en Sciences de la Santé (IRSS) / Centre National de la Recherche Scientifique et Technologique (CNRST), Ouagadougou, Burkina Faso.
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Zingue Dezemon
  • Zingue Dezemon
  • Institut National de Santé Publique (INSP), Ministère de la Santé et de l'hygiène publique, Ouagadougou, Burkina Faso.
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Zida Sylvie
  • Zida Sylvie
  • Institut de Recherche en Sciences de la Santé (IRSS) / Centre National de la Recherche Scientifique et Technologique (CNRST), Ouagadougou, Burkina Faso.
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Dabiré Charlemagne
  • Dabiré Charlemagne
  • Institut de Recherche en Sciences de la Santé (IRSS) / Centre National de la Recherche Scientifique et Technologique (CNRST), Ouagadougou, Burkina Faso.
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Kagambega Alidou
  • Kagambega Alidou
  • Institut de Recherche en Sciences de la Santé (IRSS) / Centre National de la Recherche Scientifique et Technologique (CNRST), Ouagadougou, Burkina Faso.
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Sawadogo Charles
  • Sawadogo Charles
  • Direction des Laboratoires de Biologie Médicale (DLBM), Ministère de la santé et de l’hygiène publique, Ouagadougou, Burkina Faso.
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Yabre Zakaria
  • Yabre Zakaria
  • Direction des Laboratoires de Biologie Médicale (DLBM), Ministère de la santé et de l’hygiène publique, Ouagadougou, Burkina Faso.
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Sangare Lassana
  • Sangare Lassana
  • Unité de Formation et de Recherche en Sciences de la Santé (UFR-SDS), Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.
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  •  Received: 08 July 2022
  •  Accepted: 01 November 2022
  •  Published: 30 November 2022

Abstract

This study aimed to evaluate the performance of the PanbioTM Covid-19 Ag Rapid Test (Abbott) in a medical center in Ouagadougou. The PanbioTM COVID-19 Ag test was evaluated from January 26 to March 31, 2021 in symptomatic and asymptomatic patients in the medical Centre of Kossodo. A total of 268 individuals were tested by both SARS-CoV-2 RT-PCR, and antigen RDT. Of these 268 individuals, 52 were positive and 216 were negative for COVID-19 RT-PCR. The performance parameters of the test and its Kappa agreement with the RT-PCR were calculated according to the presence or absence of symptoms in the patients on one hand, and according to the time onset of symptoms on the other hand. The sensitivity of the Panbio™ COVID-19 Ag Rapid Test ranged from 29.63% (95% CI: 13.75 to 50.18) among COVID-19 asymptomatic patients, to 87.5% (95% CI: 52.91 to97.76) among symptomatic patients with symptom onset time of 1-5 days. Similarly, the Panbio™ COVID-19 Ag Rapid Test specificity was 97.3% (95% CI: 90.58 to 99.67) and 96.4% (95% CI: 91.81 to 98.82) in symptomatic and asymptomatic RT PCR negative patients. The Panbio™ COVID-19 Ag Rapid Test shows good performance in detecting COVID-19 cases in patients with a symptom onset time of less than seven (7) days. This performance is even better when the symptom onset is reduced to five (5) days. The results show that the antigen RDT is not suitable for   COVID-19 detection among asymptomatic patients.

 

Key words: COVID-19, SARS-CoV-2, diagnosis, antigen test, rapid test, point-of-care.