African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5230

Full Length Research Paper

Multi-drug resistance in Acinetobacter baumannii strains isolated from the clinical specimens of three hospitals in Tehran-Iran

Sepideh Mostofi1, Reza Mirnejad2* and Faramaz Masjedian3
  1Department of Biology, North Tehran Azad University, Tehran, Iran. 2Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. 3Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Email: [email protected]

  •  Accepted: 29 March 2011
  •  Published: 16 November 2011



The aim of this study is to carry out an investigation on multi-drug resistance inAcinetobacter baumannii strains that are isolated from clinical samples of three highly large hospitals in Tehran-Iran. This descriptive-cross sectional study was performed in three large hospitals in Tehran on 70 samples of Acinetobacter which were isolated from patients during April to November 2010. After identifying the species level by using culture and biochemical methods, in order to determine the sensitivity of 50 isolates of A. baumannii to 13 antibiotics, standard methods according to CLSI guidelines were performed. In this study, resistance to three or more than three classes of antibiotics multidrug resistance was defined. In this study, 50 A. baumannii strains, 12 A. lwoffiistrains and other Acinetobacter species were isolated from patients. The majority of isolates were from blood specimens. Isolates of A. baumannii showed the highest resistance to cefepimeceftazidimeaztreonamnorfloxacinofloxacin, ciprofloxacin and amikacin. Tobramycin and meropenem were considered as effective drugs in this study. Multi-drug resistance in these strains was 55.4%, respectively. Multi-drug resistant Acinetobacters are growing and are considered as an important threat for hospitalized patients, so a change in consumption patterns of antibiotics and control of hospital infections seems to be necessary.


Key words: Acinetobacter baumannii, nosocomial infection, multi-drug resistance, antibiogram.