African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Virulence factors expressed by Mycobacterium ulcerans strains: Results of a descriptive study

AKA N guetta*
  • AKA N guetta*
  • Unit of Mycobacteria, Institut Pasteur, Cote d Ivoire
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KAKOU-NGAZOA E. Solange
  • KAKOU-NGAZOA E. Solange
  • Platform of Molecular Biology, Institut Pasteur, Cote d Ivoire
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COULIBALY N. D.
  • COULIBALY N. D.
  • Platform of Molecular Biology, Institut Pasteur, Cote d Ivoire
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VAKOU Sabine
  • VAKOU Sabine
  • Unit of Mycobacteria, Institut Pasteur, Cote d Ivoire
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KOUADIO Kouame
  • KOUADIO Kouame
  • Department of Environment and Health, Institut Pasteur, Cote d Ivoire
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AOUSSI Serge
  • AOUSSI Serge
  • Platform of Molecular Biology, Institut Pasteur, Cote d Ivoire
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KADIO M. Constance
  • KADIO M. Constance
  • NG AFRISOL-Cote d Ivoire, Institut Pasteur, Cote d Ivoire
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KOUAKOU Helene
  • KOUAKOU Helene
  • Platform of Molecular Biology, Institut Pasteur, Cote d Ivoire
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AKE Julien
  • AKE Julien
  • MAP International, Institut Pasteur, Cote d Ivoire
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N GUESSAN Raymond
  • N GUESSAN Raymond
  • Unit of Mycobacteria, Institut Pasteur, Cote d Ivoire
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DOSSO Mireille
  • DOSSO Mireille
  • Unit of Mycobacteria, Institut Pasteur, Cote d Ivoire
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  •  Received: 22 January 2015
  •  Accepted: 06 July 2015
  •  Published: 15 July 2015

References

Adalbert L, Mohammed A, Gisela B, Fadila B, David D, Lanfranco F, Knut F, Thomas F(2000). (Union) : Diagnostic de la tuberculose par examen microscopique direct des expectorations dans les pays à faibles revenus Guide technique; Cinquième édition 2000, 60 pages.
 
Anne-Caroline C, Tresse C, Casarottoa V, Nicolas B (2013). History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease). Nat. Prod. Rep. 30:1527-1567.
http://dx.doi.org/10.1039/c3np70068b
PMid:24178858
 
Armand MO, Richard E, Edward St, Kristin A, Timothy C, John M, Brian S, Robert G, Engu A, Small P (2005). A Newly Discovered Mycobacterial Pathogen Isolated from Laboratory Colonies of Xenopus Species with Lethal Infections Produces a Novel Form of Mycolactone, the Mycobacterium ulcerans Macrolide Toxin. Infect. Immun. 73(6):3307-3312.
http://dx.doi.org/10.1128/IAI.73.6.3307-3312.2005
PMid:15908356 PMCid:PMC1111873
 
Armand MO, Richard E, Portaels F, Small PL (2003). Heterogeneity of Mycolactones Produced by Clinical Isolates of Mycobacterium ulcerans: Implications for Virulence. Infect. Immun. 71(2):774-783.
http://dx.doi.org/10.1128/IAI.71.2.774-783.2003
PMCid:PMC145382
 
Brian SR, Engy AM, Lydia M, Sarojini A, Richard EL, Angelo C, Martha R, Small PL (2006). Globally Distributed Mycobacterial Fish Pathogens Produce a Novel Plasmid-Encoded Toxic Macrolide, Mycolactone F. Infection and Immunity. 74(11):6037-6045.
http://dx.doi.org/10.1128/IAI.00970-06
PMid:16923788 PMCid:PMC1695495
 
Caroline D, Timothy S, Stewart TC (2009). Buruli ulcer: reductive evolution enhances pathogenicity of M. ulcerans. Nat. Rev. Microbiol. 7:50-60.
http://dx.doi.org/10.1038/nrmicro2077
PMid:19079352
 
Eddyani M, Fraga AG, Schmitt F, Uwizeye C, Fissette K, Johnson C, Aguiar J, Sopoh G, Barogui Y, Meyers WM, Pedrosa J, Portaels F (2009). Fine-needle aspiration, an efficient sampling technique for bacteriological diagnosis of non-ulcerative Buruli ulcer. J. Clin. Microbiol. 47(6):1700-1704.
http://dx.doi.org/10.1128/JCM.00197-09
PMid:19386847 PMCid:PMC2691074
 
Elise SN, Euloge E, Nguetta A, David CN, Bakary C, Mireille D (2011). Evaluation of real-time PCR for Mycobacterium ulcerans in endemic region in Côte d'Ivoire. Afr. J. Microbiol. Res. 5(16):2211-2216.
 
Emmanuelle C, Jérémie D, Angelo M, Aurélie B, Nathalie W, Stewart TC, Matthew LA, Caroline D (2007). Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone J. Exp. Med. 204(6): 1395-1403.
http://dx.doi.org/10.1084/jem.20070234
PMid:17517970 PMCid:PMC2118602
 
Fred S Sarfo, Richard O Phillips, Jihui Zhang, Mohammed K Abass, Justice Abotsi, Yaw A Amoako, Yaw Adu-Sarkodie, Clive Robinson, Mark H Wansbrough-Jones (2014): Kinetics of mycolactone in human subcutaneous tissue during antibiotic therapy for Mycobacterium ulcerans disease. BMC Infect. Dis. 14:202.
http://dx.doi.org/10.1186/1471-2334-14-202
PMid:24731247 PMCid:PMC4021496
 
Fred SS, Fabien LC, N'Guetta A, Richard OP, Yaw A, Ivo GB, Pascal L, Mireille D, Mark WJ, Romain VC, Laure GM, Caroline D (2011). Mycolactone Diffuses into the Peripheral Blood of Buruli Ulcer Patients - Implications for Diagnosis and Disease Monitoring. PLoS Negl. Trop. Dis. 5(7):e1237.
http://dx.doi.org/10.1371/journal.pntd.0001237
PMid:21811642 PMCid:PMC3139662
 
Fyfe JA, Lavender CJ, Johnson PD, Globan M, Sievers A, Azuolas J, Stinear TP (2007). Development and application of two multiplex real-time PCR assays for the detection of Mycobacterium ulcerans in clinical and environmental samples. Appl. Environ. Microbiol. 73(15):4733-4740.
http://dx.doi.org/10.1128/AEM.02971-06
PMid:17526786 PMCid:PMC1951036
 
Hong H, Demangel C, Pidot SJ, Leadlay PF, Stinear T (2008). Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria. Nat Prod Rep. 25:447-454.
http://dx.doi.org/10.1039/b803101k
PMid:18497894 PMCid:PMC2730631
 
Hong H, Stinear T, Skelton P, Spencer JB, Leadlay PF (2005) Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry. Chem. Commun. 14:4306-4308.
http://dx.doi.org/10.1039/b506835e
PMid:16113730
 
Hurtado RO, Aguilar L, Orozco HE, Martin A, Luna JH, Flores LR, Portaels F, Hernandez RP (2009). Differences in virulence and immune response induced in a murine model by isolates of Mycobacterium ulcerans from different geographic areas. Clin. Exp. Immunol. 157(2):271-281.
http://dx.doi.org/10.1111/j.1365-2249.2009.03941.x
PMid:19604267 PMCid:PMC2730853
 
Kathleen M, Delphi C, Geewananda G, Diane W, Hayman J, Richard L, Small PL (1999). Mycolactone: A polyketide toxin from Mycobacterium ulcerans required for virulence. Science 283(5403):854-857.
http://dx.doi.org/10.1126/science.283.5403.854
 
Laurence A, Aka N, Euloge E, Samir B, Raymond N, Mireille D (2009). Risk factors for Buruli ulcer in Côte d'Ivoire: Results of a case-control study. Afr. J. Biotechnol. 8 (4):536-546.
 
Mac C, Toh JC, Buckle G, Sis-Sons HA (1948). A new bacterial infection in man: clinical aspects. J. Pathol. Bacteriol. 60:93-101.
http://dx.doi.org/10.1002/path.1700600111
 
Miriam E, Caroline L, Willem BR, Pieter B, Janet F, Bouke J, Portaels F (2014). Multicenter external quality assessment program for PCR detection of Mycobacterium ulcerans in clinical and environmental specimens. PLoS ONE 9(2): e89407. doi:10.1371/journal.pone.0089407.
http://dx.doi.org/10.1371/journal.pone.0089407
 
Phillips R, Horsfield C, Kuijper S, Sarfo SF, Obeng-Baah J, Etuaful S, Nyamekye B, Awuah P, Nyarko KM, Osei-Sarpong F, Lucas S, Kolk AH, Wansbrough JM (2006). Cytokine response to antigen stimulation of whole blood from patients with Mycobacterium ulcerans disease compared to that from patients with tuberculosis. Clin. Vaccine Immunol. 13(2):253-257.
http://dx.doi.org/10.1128/CVI.13.2.253-257.2006
PMid:16467334 PMCid:PMC1391935
 
Portaels F, Meyers WM, Ablordey A, Castro AG, Chemlal K, De Rijk P, Elsen P, Fissette K, Fraga AG, Lee R, Mahrous E, Small PL, Stragier P, Torrado E, Van Aerde A, Silva MT, Pedrosa J (2008). First Cultivation and Characterization of Mycobacterium ulcerans from the Environment. PLoS Negl. Trop. Dis. 2(3):e178.
http://dx.doi.org/10.1371/journal.pntd.0000178
PMid:18365032 PMCid:PMC2268003
 
Sacha JP, Hui H, Torsten S, Jessica LP, Marcus JY, Artem M, Matthew J, Peter W, John KD, Peter FL, Stinear TP (2005). Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones. J. Bacteriol. 187(5):1668-1676.
 
Sarojini A, Armand MO, Tim S, Meyers W, Hayman J, Small PL (2005). Mycobacterium ulcerans toxic macrolide, mycolactone modulates the host immune response and cellular location of Mycobacterium ulcerans in vitro and in vivo. Cell. Microbiol. 7(9):1295-1304.
http://dx.doi.org/10.1111/j.1462-5822.2005.00557.x
PMid:16098217
 
Stinear TP, Ross BC, Davies JK, Marino L, Robins-Browne RM, Oppedisano F, Sievers A, Johnson PD (1999). Identification and characterization of IS2404 and IS2606: two distinct repeated sequences for detection of Mycobacterium ulcerans by PCR. J. Clin. Microbiol. 37:1018-23.
PMid:10074520 PMCid:PMC88643
 
Stinear TP, Seemann T, Pidot S, Frigui W, Reysset G, Garnier T, Meurice G, Simon D, Bouchier C, Laurence M, Tichit M, Porter JL, Ryan J, Johnson PD, Davies JK, Jenkin GA, Small PL, Jones LM, Tekaia, Laval F, Daffé M, Parkhill J, Cole ST (2007). Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Gen. Res. 17: 192-200.
http://dx.doi.org/10.1101/gr.5942807
PMid:17210928 PMCid:PMC1781351
 
Sylvain A, Richard EL, Engy AM, Small PL, Dia B, Yoshito K (2008). Synthesis and structure of Mycolactone E isolated from Frog. Org. let. 12(23): 5385-5388.
 
Timothy PS, Hui H, Wafa F, Melinda JP, Roland B, Thierry G, Peter FL, Stewart TC (2005). Common Evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans. J. Bacteriol. 187(5): 1668-1676.
http://dx.doi.org/10.1128/JB.187.5.1668-1676.2005
PMid:15716437 PMCid:PMC1064021
 
Timothy PS, Melinda JP, Jessica LP, Stewart TC (2005). Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans. Microbiology 151: 683-692.
http://dx.doi.org/10.1099/mic.0.27674-0
PMid:15758215
 
Timothy S, Armand MO, Small PL, Wafa F, Melinda JP, Roland B, Grant AJ, Paul DR, John KD, Richard EL, Sarojini A, Thierry G, Stephen FH, Peter F, Leadlay, Stewart TC (2004). Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. PNAS 101(5):1345-1349.
http://dx.doi.org/10.1073/pnas.0305877101
PMid:14736915 PMCid:PMC337055
 
Travis M. Gooding, Paul D. R. Johnson, Dianne E. Campbell, John A. Hayman, Elizabeth L. Hartland, Andrew S. Kemp, Roy M. Robins-Browne (2001): Immune response to infection with Mycobacterium ulcerans. Infect. Immun. 69(3) :1704-1707.
http://dx.doi.org/10.1128/IAI.69.3.1704-1707.2001
PMid:11179346 PMCid:PMC98075
 
Yoshito K (2011) Chemistry of Mycolactones, the causative toxins of Buruli ulcer. PNAS 108(17):6703-6708.
http://dx.doi.org/10.1073/pnas.1015252108
PMid:21383136 PMCid:PMC3084064

 

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