African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 368

Full Length Research Paper

One-pot synthesis of some (1H)-quinoxalin-2-ones

Wageeh Salih El-Hamouly*, Eman Moustafa Hassan Abbas and Hanaa Awadallah Tawfik
Department of Natural Products, National Research Centre, Dokki, Giza, Egypt
Email: [email protected]

  •  Published: 31 January 2009

Abstract

o-phenylenediamine and 4-benzoyl-1,2-diaminobenzene react with ethyl bromoacetate in basic medium under mild reaction conditions to give directly 1H-quinoxalin-2-one (2) and 7-benzoyl-1H-quinoxalin-2-one (4), respectively. Alkylation at the nitrogen atoms of 7-benzoyl-3,4-dihydro-1H-quinoxalin-2-one (3) and compound 4 has been also carried out.

 

Key words: o-phenylenediamines, 3,4-dihydro-1H-quinoxalin-2-ones, 1H-quinoxalin-2-ones, ethyl bromoacetate.