African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

E-Cadherin, beta-catenin and HER2 expression in prostate cancer tissues with perineural invasion and their correlation with Gleason score: A preliminary study

Sandra Regina Bonfim Rodrigues
  • Sandra Regina Bonfim Rodrigues
  • Disciplina de Onco - Hematologia da Faculdade de Medicina do ABC, Santo André, SP, Brazil.
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Maylla Yabiko
  • Maylla Yabiko
  • Disciplina de Onco - Hematologia da Faculdade de Medicina do ABC, Santo André, SP, Brazil.
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Rafael Bazan Thomaz
  • Rafael Bazan Thomaz
  • Disciplina de Onco - Hematologia da Faculdade de Medicina do ABC, Santo André, SP, Brazil.
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Therese Theodoro
  • Therese Theodoro
  • Disciplina de Onco - Hematologia da Faculdade de Medicina do ABC, Santo André, SP, Brazil.
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Beatriz Alves
  • Beatriz Alves
  • Disciplina de Onco - Hematologia da Faculdade de Medicina do ABC, Santo André, SP, Brazil.
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Ligia Ajaime Azzalis
  • Ligia Ajaime Azzalis
  • Instituto de Ciências Ambientais, Químicas e Farmacêuticas- UNIFESP - Campus Diadema, Diadema, SP, Brazil.
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Edimar Cristiano Pereira
  • Edimar Cristiano Pereira
  • Instituto de Ciências Ambientais, Químicas e Farmacêuticas- UNIFESP - Campus Diadema, Diadema, SP, Brazil.
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Virginia Berlanga Campos Junqueira
  • Virginia Berlanga Campos Junqueira
  • Instituto de Ciências Ambientais, Químicas e Farmacêuticas- UNIFESP - Campus Diadema, Diadema, SP, Brazil.
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Roseli Corazzini
  • Roseli Corazzini
  • Disciplina de Onco - Hematologia da Faculdade de Medicina do ABC, Santo André, SP, Brazil.
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Fernando Adami
  • Fernando Adami
  • Disciplina de Onco - Hematologia da Faculdade de Medicina do ABC, Santo André, SP, Brazil.
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Fernando Luiz Affonso Fonseca*
  • Fernando Luiz Affonso Fonseca*
  • 1. Disciplina de Onco - Hematologia da Faculdade de Medicina do ABC, Santo André, SP, Brazil. 2. Instituto de Ciências Ambientais, Químicas e Farmacêuticas- UNIFESP - Campus Diadema, Diadema, SP, Brazil.
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  •  Accepted: 11 February 2014
  •  Published: 15 February 2014

Abstract

Prostate cancer (PC) is the most common malignant tumor in men. Early identification of prostate cancer may result in improved cure rates and increased life expectancies. Gleason score and clinical range at the time of diagnosis are important factors to predict prognosis and outcome after therapy but additional accurate and reliable biomarkers are warranted. Few biomarkers of prostate cancer have been successfully implemented and used in clinical practice. In this study, we sought to determine the expression of E-cadherin, beta-catenin and human epidermal receptor (HER2) in biopsy specimens of prostate cancer with perineural invasion, and correlate them with Gleason score in order to verify the relationship between those markers and prostate cancer process. Our study demonstrated abnormal expression of E-cadherin, beta-catenin and HER2. On the other hand, our results showed no correlation between Gleason score and the expression of those markers in invasive prostate cancer tissues. Other different biomarkers remain to be identified, that potentially could improve the evaluation of prognostic of the patient.

Key words: Biomarkers, biopsy specimens, Gleason score, perineural invasion, prostate cancer.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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