African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

DPPH radical scavenging and lipoxygenase inhibitory effects in extracts from Erythrina senegalensis (Fabaceae) DC

Fofana Souleymane
  • Fofana Souleymane
  • Laboratory of pharmacology, Pharmacy, University of Ouagadougou, P.O. Box 7021, Burkina Faso
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Gnoula Charlemagne
  • Gnoula Charlemagne
  • Laboratory of pharmacology, Pharmacy, University of Ouagadougou, P.O. Box 7021, Burkina Faso
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Ouédraogo Moussa
  • Ouédraogo Moussa
  • Laboratory of pharmacology, Pharmacy, University of Ouagadougou, P.O. Box 7021, Burkina Faso
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Palé Eloi
  • Palé Eloi
  • Centre of Biomolecular Rechearch Pietro Annigoni (CERBA)/Saint-Camille in Ouagadougou, Burkina Faso.
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Nébié Roger HC
  • Nébié Roger HC
  • Laboratory of Biology and Molecular Genetics, Faculty of Sciences, University of Ouagadougou, P.O. Box 7021, Burkina Faso.
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Nikiema Jean Baptiste
  • Nikiema Jean Baptiste
  • Laboratory of pharmacology, Pharmacy, University of Ouagadougou, P.O. Box 7021, Burkina Faso
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Guissou Innocent Pierre
  • Guissou Innocent Pierre
  • Laboratory of pharmacology, Pharmacy, University of Ouagadougou, P.O. Box 7021, Burkina Faso
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Simpore Jacques
  • Simpore Jacques
  • Centre of Biomolecular Rechearch Pietro Annigoni (CERBA)/Saint-Camille in Ouagadougou, Burkina Faso.
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  •  Received: 04 October 2015
  •  Accepted: 09 November 2015
  •  Published: 22 March 2016

Abstract

Erythrina senegalensis DC (Fabaceae) is a plant used in traditional medicine in Burkina Faso (West Africa) to cure several diseases such as malaria, rheumatism, abdominal pain, fibroma and infections which are always accompanied by oxidative stress. This study aimed to highlight the antioxidant activities in dichloromethane (DCM) and ethyl acetate (EtOAc) extracts of E. senegalensis stem bark and roots. We used the 1, 1 diphenyl-2-picryl hydrazyl (DPPH) radical scavenging test and the 12-lipoxygenase I-B inhibitory method. We previously characterized the phytochemical groups by thin layer chromatography and colored reactions in tubes. The extracts in DCM (IC50-root: 5.18 ± 0.06 and IC50-bark: 5.76 ± 0.68) showed strong scavenging activity. However, as a 12-lipoxygenase inhibition, the DCM extracts were almost inactive. The EtOAc extracts from root (IC50-LOX: 7.21 ± 2.31; IC50-DPPH: 7.27 ± 0.13) and from stem bark (IC50-LOX : 4.95 ± 1.12; IC50-DPPH : 11.4 ± 1.3) presented both the radical scavenging and the 12-lipoxygenase inhibitory effects. Polyphenols (flavonoids, tannins), steroids and terpenoids characterized in all extracts may be involved in the observed 12-lipoxygenase inhibition and radical scavenging. 

Key words: E. senegalensis, antioxidant, 12-lipoxygenase I-B inhibitory.

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