African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Investigation of zoledronic acid induced stress on rabbit kidneys with oxidative stress markers

?imay Gürocak*
  • ?imay Gürocak*
  • Department of Radiation Oncology, Inonu University School of Medicine, Malatya-Turkey
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Mehmet Gül
  • Mehmet Gül
  • Department of Histology and Embriology, Inonu University School of Medicine, Malatya-Turkey
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Ercan Karabulut
  • Ercan Karabulut
  • Department of Pharmacology Çukurova University, Adana-Turkey
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Tugba Raika K?ran
  • Tugba Raika K?ran
  • Department of Biochemistry, Inonu University School of Medicine, Malatya-Turkey.
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Aysun Bay Karabulut
  • Aysun Bay Karabulut
  • Department of Biochemistry, Inonu University School of Medicine, Malatya-Turkey.
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  •  Received: 28 June 2013
  •  Accepted: 07 October 2014
  •  Published: 29 October 2014

Abstract

In this study, we aimed to investigate the effect of zoledronic acid, which is  a potent  bisphosphonate  on  oxidative stress  markers in rabbit kidney tissue. As an oxidative stress marker, malondialdehyde, nitric oxide, glutathione were studied. Rabbits were given daily 100 μg/kg zoledronic acid for 28 days (n = 7) in the study group. Control group (n = 7) rabbits were fed ad libitum for the same period. Malondialdehyde and nitric oxide levels were statistically significantly higher in the zoledronic acid group (p <0.0001). However, glutathione activity was statistically significantly lower (p <0.0001) compared to the control. Rabbit kidney tissues were examined histopathologically. The histopathological changes between the groups were not significantly different. In conclusion, we showed that zoledronic acid may induce oxidative stress by reducing antioxidant levels in rabbit kidney tissues.  Further human studies are needed to clarify the adverse effects of zoledronic acid.

 

Key words: Zoledronic acid, oxidative stress, malondialdehyde, glutathione, nitric oxide.

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